基于知识图谱的复发性流产中医药研究

Research on the Treatment of Recurrent Spontaneous Abortion with Traditional Chinese Medicine based on Knowledge Graph

[目的]基于知识图谱对复发性流产(recurrent spontaneous abortion,RSA)中医药研究现状进行分析,展示RSA中医药研究的研究热点和前沿。[方法]在知网、维普、万方数据库搜索,从建库到2022年2月与RSA中医药相关的研究。采用COOC 10.07、VOSviewer软件绘制发文量、机构、作者及关键词的知识图谱,分析其特点及演化趋势。[结果]共检索到相关文献990篇,发文量整体呈增长趋势,形成了以冯晓玲、卫爱武、谈勇、雷磊等为学术带头人的研究团队,研究机构主要为高校及其附属医院,作者合作与机构合作未能形成紧密网络,合作有待加强。关键词分析显示,RSA中医药研究主要集中在辨证论治、病因病机、治疗方法。研究热点及前沿侧重于免疫因素、血栓前状态(pre-thrombolic state,PTS)及不明原因导致的RSA研究,并致力于机制性研究来阐明中医药治疗RSA的有效性。[结论]通过知识图谱直观展现了RSA中医药研究的研究方向、研究热点、演化趋势,以及各研究机构间缺乏深度、广度合作的问题,为进一步的临床及相关实验研究提供方向和思路。

[Objective] To analyze the research status of traditional Chinese medicine for recurrent spontaneous abortion(RSA) based on knowledge graph, and to show the research hotspots and frontiers of traditional Chinese medicine researches on RSA. [Methods] Searched China National Knowledge Infrastructure(CNKI), China Science and Technology Journal Database(VIP), and Wanfang Database for researches related to RSA Chinese medicine from the establishment date of the database to February 2022. COOC 10.07 and VOSviewer software were used to draw a knowledge graph of the number of published articles, institutions, authors and keywords, and analyze their characteristics and evolution trends. [Results] A total of 990 relevant documents were retrieved, and the overall number of published articles showed an increasing trend. Research teams with FENG Xiaoling, WEI Aiwu, TAN Yong, LEI Lei and others as academic leaders were formed. The research institutions were mainly universities and their affiliated hospitals. Authors cooperation and institutional cooperation failed to form a close network, and the cooperation needed to be strengthened. Keyword analysis showed that the research on RSA Chinese medicine mainly focused on syndrome differentiation and treatment, etiology and pathogenesis, and treatment methods.Research hotspots and frontiers focused on the RSA which was caused by immune factors, pre-thrombolic state(PTS) and unexplained reasons. And recently researchers were dedicated to mechanism researches to clarify the effectiveness of traditional Chinese medicine in the treatment of RSA. [Conclusion] The knowledge graph intuitively shows the research direction, research hotspots, evolution of RSA TCM researches, and the lack of depth and breadth cooperation between research institutions, which provides direction and ideas for further clinical and related experimental researches.