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高压氧综合治疗对胫腓骨骨折患者预后和血清碱性磷酸酶水平的影响 被引量:4

Effect of hyperbaric oxygen therapy on prognosis and serum bone alkaline phosphatase level of patients with open tibiofibular fracture
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摘要 目的探讨高压氧综合治疗方式在胫腓骨骨折患者术后治疗中的应用效果。方法选取山西白求恩医院2018年10月至2019年10月收治的97例胫腓骨骨折患者,以随机数字表法分为对照组48例和观察组49例,术后对照组给予常规物理治疗,观察组给予高压氧综合治疗,比较2组患者的治疗效果、不同时间点血清碱性磷酸酶(AKP)水平及并发症发生率。结果观察组患者治疗有效率(91.84%)高于对照组(81.25%),差异有统计学意义(P<0.05)。术后2~3周,2组患者血清AKP水平均明显上升且达到峰值,观察组患者血清AKP水平高于对照组,差异有统计学意义(P<0.05);术后4~6周,观察组患者血清AKP水平下降明显,且低于对照组,差异有统计学意义(P<0.05);观察组患者血清AKP水平随后持续下降,至12周时,2组差异无统计学意义(P>0.05)。对照组患者术后并发症发生率(27.08%)高于观察组(8.16%),差异有统计学意义(P<0.05)。结论高压氧综合治疗应用于胫腓骨骨折患者的术后治疗,疗效确切,能显著改善骨折患者的血清AKP活性,并降低并发症的发生率。 Objective To investigate the effect of hyperbaric oxygen adjuvant therapy in the postoperative treatment of the patients with emergency open tibiofibular fracture.Methods A total of 97 patients with open tibiofibular fracture admitted to the Shanxi Bethune Hospital from October 2018 to October 2019,were randomly divided into control group(48 cases)and observation group(49 cases),according to the random table method.After operation,the control group was given conventional physical therapy,while the observation group was given hyperbaric oxygen adjuvant therapy on the basis of the conventional treatment.The therapeutic effect,serum alkaline phosphatase(AKP)level at different time points,and the incidence of complications of the two groups were compared.Results The effective rate of the observation group(91.84%)was higher than that of the control group(81.25%),with statistically significant difference(P<0.05).Two to three weeks after operation,the serum AKP activities in both groups were high and reached the peak,and the AKP level of the observation group was significantly higher than that of the control group,with statistically significant difference(P<0.05).Four to six weeks after operation,the serum AKP activity of the observation group was significantly reduced,and it was lower than that of the control group,with statistically significant difference(P<0.05).Then the serum AKP level and activity of the observation group had continuously declined until at 12 weeks after operation when there was no significant difference between the two groups(P>0.05).The incidence of postoperative complication of the control group(27.08%)was higher than that of the observation group(8.16%),and the difference was statistically significant(P<0.05).Conclusion Hyperbaric oxygen adjuvant therapy has a marked curative effect in the postoperative treatment of the patients with open tibiofibular fracture.It can significantly improve the activity of serum bone AKP and reduce the incidence of complication.
作者 吴志明 赵惠琴 张建国 Wu Zhiming;Zhao Huiqin;Zhang Jianguo(Department of Emergency Surgery,Shanxi Bethune Hospital(The Third Hospital of Shanxi Medical University),Taiyuan 030032,China)
出处 《中华航海医学与高气压医学杂志》 CAS CSCD 2022年第5期620-623,共4页 Chinese Journal of Nautical Medicine and Hyperbaric Medicine
关键词 高压氧 胫腓骨骨折 预后 碱性磷酸酶 Hyperbaric oxygen Tibiofibular fracture Prognosis Alkaline phosphatase
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