一例犬脑膜内皮型脑膜瘤的诊治

Diagnosis and treatment of a canine meningeal endothelial meningioma

1只雄性金毛寻回猎犬,10.6岁,四肢无力,共济失调、本体感觉减弱(左侧严重),双眼瞳孔对光反射正常。血细胞计数检查结果未见明显异常。血清生化指标检查结果显示,血糖含量为7.07 mmol/L(参考范围为3.30~6.10 mmol/L),轻微偏高,其他未见明显异常。心脏超声心动检查结果提示左心收缩功能减退。磁共振成像(MRI)检查结果提示右侧颞顶区存在T2高信号且肿块引起右侧脑室压迫和移位,使用造影剂后肿块均匀增强,且肿块边缘有清晰的“硬膜尾征”,提示为轴外肿物。行颅脑切开术切除肿物,病理组织学分析该肿物为脑膜瘤(脑膜内皮型,WHOⅠ级)。术后1周未见癫痫发作,预后良好。说明脑膜瘤早期的外科干预能有效控制患犬的神经症状。

A male Golden Retriever was 10.6 years old,with limb weakness,ataxia,diminished proprioception,and severe symptoms in the left limbs.The pupils of both eyes had normal light reflexes.The results of blood cell count test showed no obvious abnormality.The test results of serum biochemical indicators showed that the blood glucose content was 7.07 mmol/L(the reference range was 3.30-6.10 mmol/L),which was slightly high,and no other obvious abnormalities were found.Examination results of cardiac echocardiographic suggested left ventricular systolic dysfunction.Magnetic resonance imaging(MRI)examination results showed that there was T2 hyperintensity in the right temporoparietal region and the mass caused compression and displacement of the right ventricle;the mass was uniformly enhanced after the use of contrast agents,and there was a clear“dural tail sign”on the edge of the mass,suggesting that an extra-axial tumor.A craniotomy was performed to remove the tumor,which was found to be a meningioma(meningeal endothelial type,WHO gradeⅠ)on histopathological analysis.No epilepsy was seen one week after the operation,and the prognosis was good.The results suggested that the early surgical intervention of meningioencephaloma could effectively control the neurological symptoms of dogs.