调控巨噬细胞促进周围神经再生的研究进展

Research progress in promotion of peripheral nerve regeneration by regulating macrophages

对调控巨噬细胞促进周围神经再生中的相关研究进展进行综述,为周围神经损伤的研究及临床治疗提供新思路。上海交通大学附属第一人民医院创伤中心查阅从2013年至2021年国内外调控巨噬细胞促进周围神经再生的相关文献,并进行分析和总结。从2013年至2021年的研究中,发现在神经损伤治疗中调控巨噬细胞相关功能可以有效改善神经损伤的预后,主要通过从M1巨噬细胞极化为M2巨噬细胞、增加胞吞作用、改变巨噬细胞表型等方面发挥作用。充分研究巨噬细胞相关特性,并对巨噬细胞功能和表型进行有益的调控,为周围神经损伤的治疗提供了一种新思路及重要研究方向。

This article reviews the research progress in promotion of peripheral nerve regeneration by regulating macrophages,a new idea for the research and treatment of peripheral nerve injury.The Trauma Center of The First People's Hospital Affiliated to Shanghai Jiao Tong University reviewed the relevant literatures in the regulation of macrophages on peripheral nerve regeneration at home and abroad,from 2013 to 2021,were reviewed and analysed.Of the study from 2013 to 2021,autologous nerve transfer was the main option in the treatment of peripheral nerve injury,but it has many setbacks such as insufficient donor,new nerve injury and local neuroma.Modulating macrophage-related function can effectively improve the prognosis of nerve injury.In recent years,the regulation of macrophages in the treatment of nerve injury is mainly through the mechanism of M1 macrophages polarisation to M2 macrophages,increase of phagocytosis,change of the phenotype of macrophages,and so on.By studying the characteristics of macrophages and regulating the function and phenotype of macrophages,it would provide a new idea and important research direction in the treatment of peripheral nerve injury.