基于数据挖掘探讨国医大师韩明向辨治眩晕的经验研究

A study on the experience of TCM master HAN Mingxiang in the treatment of vertigo based on data mining

目的:探究归纳韩明向教授辨治眩晕的选方用药经验。方法:收集韩明向门诊眩晕患者的临床案例,运用Excel软件建立数据库,对证型、高频药物、性味归经进行统计分析;并用SPSS、Cytoscape等进行关联规则分析及聚类分析。结果:共纳入处方108首,证型多为气血亏虚证、肝肾阴虚证。涉及药物195味,以补虚药为主;药物性味以温平、甘辛为主,多归肝脾肾经。高频药物包括陈皮、黄芪、柴胡、炙甘草、茯苓等;常用药对有黄芪-升麻、天麻-钩藤、白术-厚朴-陈皮等。聚类分析涉及六味地黄丸、丹栀逍遥散、补中益气汤等方剂。结论:韩明向教授治疗眩晕经验为标本兼治、补虚为主,肝脾同调、辛甘同用,并随证搭配平肝潜阳、解郁化火、燥湿祛痰、活血化瘀等治法。

Objective:To explore the experience of Professor HAN Mingxiang in the selection and use of prescriptions for the treatment of vertigo.Methods:Clinical cases of Han Mingxiang’s outpatients were collected,and a database was built by Excel software.Statistical analysis was conducted on syndrome types,high-frequency drugs,medicinal tastes,medicinal properties,and meridian tropism,and the association rule analysis and cluster analysis were performed by SPSS and Cytoscape.Results:A total of 108 prescriptions were included,with most of the syndrome types of Qi(气)and blood deficiency,and liver and kidney Yin(阴)deficiency;195 drugs were involved,with deficiency tonic drugs as the main ones;the medicinal tastes of drugs were mainly warm and flat,sweet and pungent,and mostly belonged to the liver,spleen and kidney meridians;the high frequency drugs included Chenpi(Tangerine peel),Huangqi(Astragalus membranaceus),Chaihu(Bupleurum),Zhi Gancao(Processed licorice),Fuling(Poria cocos),etc..The common medicine pairs were Huangqi-Shengma(Cohosh),Tianma(Gastrodia elata)-Gouteng(Uncaria),Baizhu(tractylodes)-Houpo(Magnolia officinalis)-Chenpi.The cluster analysis involved prescriptions such as Liuwei Dihuang Wan(六味地黄丸),Danzhi Xiaoyao San(丹栀逍遥散),and the Buzhong Yiqi decoction(补中益气汤).Conclusion:Professor HAN Mingxiang's experience in the treatment of vertigo is to treat both the symptoms and root causes,and mainly to enhance body resistance.The liver and spleen are treated simultaneously,and the treatment methods such as leveling the liver and promoting Yang(阳),relieving depression and dispelling fire,drying dampness and dispelling phlegm,and promoting blood circulation and removing stasis are applied according to the syndromes.