孕晚期GBS感染孕妇蜕膜间质细胞死亡值、血清炎性因子对妊娠结局的预测价值

Predictive Value in Cell Death Values of Decidual Stromal Cells and Serum Inflammatory Factors in Pregnant Women Infected with GBS in Third Trimester of Pregnancy

目的探究孕晚期B族链球菌(GBS)感染孕妇蜕膜间质细胞死亡值、血清炎性因子对妊娠结局的预测价值。方法选取2020年1月—2022年1月收治的85例孕晚期GBS感染孕妇作为研究组,另选同期85例孕晚期无GBS感染孕妇作为对照组。比较2组一般资料、蜕膜间质细胞死亡值及血清炎性因子[白细胞介素-6(IL-6)、IL-1β、肿瘤坏死因子-α(TNF-α)]水平,采用Pearson相关系数模型分析研究组蜕膜间质细胞死亡值与血清IL-6、IL-1β、TNF-α水平的相关性。比较研究组不同妊娠结局孕妇蜕膜间质细胞死亡值及血清IL-6、IL-1β、TNF-α水平,并采用受试者工作特征(ROC)曲线评价蜕膜间质细胞死亡值及血清IL-6、IL-1β、TNF-α预测孕晚期GBS感染孕妇不良妊娠结局的价值。结果研究组蜕膜间质细胞死亡值及血清IL-6、IL-1β、TNF-α水平均高于对照组(P<0.01);研究组蜕膜间质细胞死亡值与血清IL-6、IL-1β、TNF-α水平呈正相关(r=0.762、0.772、0.721,P<0.01)。研究组妊娠结局不良孕妇蜕膜间质细胞死亡值及血清IL-6、IL-1β、TNF-α水平均高于妊娠结局良好孕妇(P<0.01)。蜕膜间质细胞死亡值及血清IL-6、IL-1β、TNF-α水平单独预测孕晚期GBS感染孕妇不良妊娠结局的曲线下面积(AUC)均>0.7,联合预测的AUC最大,为0.903。结论孕晚期GBS感染孕妇蜕膜间质细胞死亡值及血清IL-6、IL-1β、TNF-α水平明显升高,孕晚期检测上述指标可辅助临床预测不良妊娠结局的发生风险。

Objective To explore the predictive value of cell death value of decidual stromal cells and serum inflammatory factors in pregnant women infected with Group B streptococcus(GBS)in the third trimester of pregnancy.Methods From January 2020 to January 2022,85 pregnant women with GBS infection in the third trimester of pregnancy were selected as the research group,and 85 pregnant women without GBS infection in the third trimester of pregnancy during the same period were selected as the control group.The general data,cell death value of decidual stromal cells and serum inflammatory factors[interleukin-6(IL-6),interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α)]of the two groups were compared.Pearson correlation coefficient model was used to analyze the correlation between cell death values of decidual interstitium and serum levels of IL-6,IL-1βand TNF-α.Cell death value of decidual stromal cells and serum levels of IL-6,IL-1βand TNF-αwere compared among pregnant women with different pregnancy outcomes in the research group,and cell death value of decidual stromal cells and serum levels of IL-6,IL-1βand TNF-αin predicting adverse pregnancy outcomes of GBS-infected women in the third trimester of pregnancy were evaluated by receiver operating characteristic(ROC)curve.Results Cell death value of decidual stromal cells and serum levels of IL-6,IL-1βand TNF-αin the research group were higher than those in the control group(P<0.01).There was a positive correlation between cell death values of the decidual interstitium and serum levels of IL-6,IL-1βand TNF-α(r=0.762,0.772,0.721,P<0.01).Cell death value of decidual stromal cells and serum levels of IL-6,IL-1βand TNF-αin the pregnant women with poor pregnancy outcome were higher than those of the pregnant women with good pregnancy outcome(P<0.01).The area under ROC curve(AUC)of cell death value of decidual stromal cells and serum levels of IL-6,IL-1βand TNF-αalone in predicting poor pregnancy outcomes of GBS-infected women in the third trimester of pregnancy were all>0.7,and the AUC of combined prediction was the largest(0.903).Conclusion The cell death value of decidual stromal cells and serum levels of IL-6,IL-1βand TNF-αwere significantly increased in pregnant women infected with GBS in the third trimester of pregnancy.Detection of these indicators in the third trimester of pregnancy can assist clinical prediction of the risk of adverse pregnancy outcomes.