药物诱导的炎症性肠病相关矛盾反应及其潜在机制

Paradoxical reactions related to drug-induced inflammatory bowel disease and the potential mechanisms

临床用药的目的在于治愈疾病,减轻患者症状,改善患者病情。然而,关于临床用药过程中引起与药物治疗作用相反或加重病情的矛盾反应事件并不罕见,其中胃肠道是此类事件常见的受累器官之一。本文将对这类治疗药物诱发或加重炎症性肠病的事件及潜在机制进行综述,以便临床医生更好地认识这类矛盾事件以及为患者选择更恰当的治疗方案。

The purpose of clinical medications is to treat the disease,reduce patients′symptoms and improve their condition.However,in recent years,paradoxical reactions that cause the opposite or aggravate the disease during clinical medication are not uncommon,and the gastrointestinal tract is one of the common organs involved in such events.This article reviews the events and potential mechanisms of inflammatory bowel disease induced or aggravated by drugs,so that clinicians can better understand such contradictory events and choose more appropriate treatment options for patients.