胃癌术后患者中医证型分布特点及与脂代谢相关性研究

A study on the correlation between the distribution characteristics of TCM syndrome and lipid metabolism in patients with gastric cancer after surgery

目的:探究胃癌术后患者中医证型的分布规律,并研究中医证型与脂代谢的相关性,为胃癌术后的中医治疗提供理论依据。方法:通过回顾性分析,收集符合纳入标准的69例胃癌术后患者的病例资料,根据其主要症状和体征聚类分析中医证型,将单因素分析后有统计学差异的脂代谢相关指标带入到二元Logistic回归分析,探究胃癌术后患者的中医证型与脂代谢相关指标的关系。结果:60例胃癌术后患者中,脾胃虚弱证26例,气血亏虚证17例,肝胃不和证15例,痰湿内蕴证11例,证型分布以脾胃虚弱证为主;脾胃虚弱证与脂代谢指标三酰甘油(Triglycerides,TG)和低密度脂蛋白胆固醇(Low-density Lipoprotein Cholesterol,LDL-C)具有相关性(P<0.05),而气血亏虚证、肝胃不和证、痰湿内蕴证与脂代谢相关指标差异均无统计学意义(P>0.05)。结论:脾胃虚弱是胃癌术后患者最常见的中医证型,乏力是最常见的症状。脾胃虚弱证与脂代谢指标TG和LDL-C具有相关性。对于胃癌术后患者而言,TG和LDL-C水平越高越容易患脾胃虚弱证。

Objective:To explore the distribution characteristics of TCM syndrome types in patients with gastric cancer after operation,and to study the correlation between TCM syndrome types and lipid metabolism,so as to provide a theoretical basis for TCM treatment of gastric cancer after operation.Methods:By the method of retrospective analysis,the data of 69 postoperative patients with gastric cancer who met the inclusion criteria was collected,and the TCM syndrome types were analyzed according to their main symptoms and signs.The lipid metabolism related indexes with statistical difference after univariate analysis were brought into binary logistic regression analysis to explore the relationship between TCM syndrome types and lipid metabolism related indexes of postoperative patients with gastric cancer.Results:Among the 69 cases,there were 26 cases of spleen and stomach weakness syndrome,17 cases of Qi(气)and blood deficiency syndrome,15 cases of liver and stomach disharmony syndrome,and 11 cases of phlegm-dampness accumulation syndrome.The TCM syndrome type with the largest proportion was the spleen and stomach weakness syndrome.There was a correlation between the spleen and stomach weakness syndrome and lipid metabolism indexes TG and LDL-C(P<0.05).There was no significant difference between the three TCM syndrome types,namely the Qi and blood deficiency syndrome,the liver and stomach disharmony syndrome,and phlegm-dampness accumulation syndrome,and lipid metabolism related indexes.Conclusion:The spleen and stomach weakness syndrome is the most common TCM syndrome type in postoperative gastric cancer patients,weakness is the most common symptom after gastric cancer surgery.The spleen and stomach weakness syndrome is related to lipid metabolism indexes TG and LDL-C.For postoperative gastric cancer patients,the higher the levels of TG and LDL-C,the more likely they are to suffer from the spleen and stomach weakness syndrome.