2014-2021年北京市麻疹风疹实验室网络运转情况分析

Performance of measles and rubella laboratory network in Beijing,2014-2021

目的分析2014—2021年北京市麻疹风疹实验室网络运转状况,综合各项指标评价网络运行质量。方法汇总2014—2021年北京市麻疹风疹实验室网络病例诊断、病原学分析、病毒基因型、职能考核等结果数据,综合网络运转情况进行统计分析。结果网络共包括21家实验室,其中市级疾病预防控制中心1家、区级疾病预防控制中心16家、医疗机构4家,各级实验室按职责和检测时限有序分工。2014—2021年网络实验室共检测疑似麻疹或风疹病例血清样本12229份,麻疹阳性率19.32%,风疹阳性率7.10%;核酸样本8100份,麻疹阳性率23.72%,风疹阳性率8.63%。麻疹病毒基因型测序1705株,分型发现H1a基因型1687株、D8基因型11株、B3基因型2株、疫苗株5株;风疹病毒基因型测序37株,其中1E基因型13株、2B基因型24株。网络每年开展质量控制和技术培训,各实验室职能考核成绩良好。结论北京市麻疹风疹实验室网络运转良好,并通过持续技术提升提高了实验室诊断敏感性和监测能力,同时通过严格的质量控制保证了实验室数据准确高效,为北京市麻疹消除和风疹防控提供有力的技术保障。

Objective To evaluate the performance of measles and rubella laboratory network in Beijing from 2014 to 2021.Methods The data about the performance of measles and rubella laboratory network in Beijing from 2014 to 2021,including case diagnosis,etiological analysis,virus genotype,assessment results,were collected for a statistical analysis.Results The network consisted of 21 laboratories,including 1 in municipal CDC,16 in district CDCs and 4 in medical institutions.The laboratories at all levels were classified according to their responsibilities and testing time limits.From 2014 to 2021,a total of 12229 serum samples of measles and rubella cases were detected by the laboratory network,the measles-positive rate was 19.32%and the rubella-positive rate was 7.10%.From 2014 to 2021,a total of 8100 nucleic acid samples were detected by the laboratory network,the measles-positive rate was 23.72%and the rubella-positive rate was 8.63%.The genotypes of 1705 measles virus strains were sequenced,and the results showed that 1687 strains belonged to genotype H1a,11 strains belonged to genotype D8,2 strains belonged to genotype B3,and 5 were vaccine strains.A total of 37 rubella virus strains were genotyped,and the results showed that there were 13 strains of genotype 1E and 24 strains of genotype 2B.Quality control and technical training were carried out every year for the laboratory network,and the assessment results of all laboratories were good.Conclusion The performance of measles and rubella laboratory network in Beijing was well,and the sensitivity of diagnosis and surveillance capability of laboratories have been improved continuously by updating of detection techniques.The accuracy and efficiency of laboratory data are ensured by strict quality control,providing strong technical support for measles elimination and rubella prevention and control in Beijing.