2016-2020年浙江省杭州市健康人群麻疹IgG抗体水平调查

IgG antibody level to measles in healthy population in Hangzhou,Zhejiang,2016-2020

目的评估2016—2020年浙江省杭州市健康人群麻疹抗体水平。方法采用分层随机抽样方法,选择杭州市11个年龄组健康人群,采用酶联免疫吸附试验检测血清麻疹IgG抗体,分析抗体阳性率和几何平均浓度(GMC)。结果杭州市健康人群麻疹IgG抗体总阳性率为89.48%(1488/1663),GMC为851.94 mIU/mL。各年龄组人群麻疹IgG抗体阳性率在58.28%(<1岁组)~98.01%(3~4岁组)(χ^(2)=198.70,P<0.001),GMC在573.44 mIU/mL(<1岁组)~1682.98 mIU/mL(1岁组)(F=23.12,P<0.01)。0、1、≥2剂次、含麻疹成分疫苗(MCV)免疫史不详的人群,麻疹IgG抗体阳性率分别为55.26%、89.19%、93.32%、91.00%(χ^(2)=155.21,P<0.01),GMC分别为418.20、1536.88、966.59、735.17 mIU/mL(F=21.68,P<0.001)。在有MCV免疫史人群中,麻疹IgG抗体阳性率、GMC分别从免疫后<1年的91.59%、1644.70 mIU/mL下降到免疫后≥10年的87.65%、649.03 mIU/mL。结论杭州市健康人群总体麻疹抗体水平较高,人群免疫水平与地区、年龄、免疫史相关,并随MCV接种后时间的延长而下降,需探讨成人麻疹免疫策略。

Objective To evaluate the IgG antibody level to measles in healthy population in Hangzhou,Zhejiang province,during 2016−2020.Methods Stratified random sampling was conducted to select 11 age groups in healthy population in Hangzhou.Enzyme linked immune sorbent assay(ELISA)was used to detect serum measles IgG antibody,and the positive rate of antibody and geometric mean concentration(GMC)were analyzed.Results The positive rate of measles IgG antibody was 89.48%(1488/1663)and measles IgG GMC was 851.94 mIU/mL in healthy population in Hangzhou.The positive rate of measles IgG antibody in all age groups ranged from 58.28%(<1 year old group)to 98.01%(3−year old group)(χ^(2)=198.70,P<0.01),the GMC was between 573.44 mIU/mL(<1 year old group)and 1682.98 mIU/mL(1-year old group)(F=23.12,P<0.01).The positivity rates and the GMCs in subjects who received 0,1,≥2 and unknown doses of measles containing vaccine(MCV)were 55.26%,89.19%,93.32%,91.00%(χ^(2)=155.21,P<0.001)and 418.20 mIU/mL,1536.88 mIU/mL,966.59 mIU/mL,735.17 mIU/mL(F=21.68,P<0.001),respectively.The positive rate of measles IgG antibody and the GMC decreased from 91.59%,1644.70 mIU/mL(<1 year after immunization)to 87.65%,649.03 mIU/mL(≥10 years after immunization)in people with history of MCV.Conclusion The overall measles IgG antibody level in healthy population in Hangzhou was high,the population immunization level was associated with area,age and immunization history and decreased over time after MCV immunization.It is necessary to make some discussion about the measles immunization strategy in adults.