基于代谢组学的中药药效评价、药效物质发现及作用机制研究进展

Research advance in efficacy evaluation, active substances and action mechanism of traditional Chinese medicine based on metabonomics

中药药效物质及作用机制等中药有效性相关问题的科学阐释是解决制约中药现代化发展的有效途径。代谢组学与中医药的整体观、辨证论治特征相契合,以其高通量、整体性的研究特性高效解析中药整体药效作用过程。将中医药理论与代谢组学技术有机融合,可为深层次阐明中药的有效性、物质基础、作用机制等科学问题提供关键技术。综述了代谢组学方法解决中药药效评价与药效物质研究的具体实践,并对代谢组学策略的未来发展方向进行展望。

The scientific explanation of the issues related to the effectiveness of traditional Chinese medicine, such as efficacy evaluation, active substances and action mechanism, is the key problem restricting the modernization of traditional Chinese medicine. Metabonomics is in line with the overall view of traditional Chinese medicine, the characteristics of syndrome differentiation and treatment, with its high-throughput and holistic research characteristics to efficiently analyze the overall pharmacodynamic process of traditional Chinese medicine. Organic integration of traditional Chinese medicine theory and metabonomics technology can provide technical support for deep-seated elucidation of scientific problems such as traditional Chinese medicine effectiveness, material basis, and mechanism of action. Therefore, this paper reviews the specific practice of metabolomics methods to solve the pharmacodynamic evaluation and pharmacodynamic substance research of traditional Chinese medicine, and looks forward to the future development direction of metabolomics strategies.