摘要
A calix[4]arene ligand assisted directβ-C-H arylation of tertiary aliphatic aldehydes has been developed via a Pd-catalyzed C(sp3)-H functionalization process.This strategy exhibited good functional group compatibility and C-H bond site-selectivity.Mechanism studies have shown that both synergistic effect and cationic-πsupramolecular interaction between calixarene cavity and transition-metal catalytic center may play an important role in this catalytic cycle.This complementary method would be used in organic and medical chemistry due to the importance of tertiary aliphatic aldehydes.
基金
the financial support from the National Natural Science Foundation of China (Nos. 21572026, 21702019)
Postgraduate Research & Practice Innovation Program of Jiangsu Province (No. KYCX20_2525)
Advanced Catalysis and Green Manufacturing Collaborative Innovation Center, Changzhou University
the analytical testing support from Analysis and Testing Center, NERC Biomass of Changzhou University
