基于MIMICS建模与SimVascular仿真计算的椎基底动脉交界区开窗与后循环脑梗死相关性研究

Correlation Between Windowing of the Vertebrobasilar Artery Junction and Posterior Circulatory Cerebral Infarction Based on MIMICS Modeling and SimVascular Simulation Calculations

目的探讨椎基底动脉交界区开窗血液流变特性与后循环脑梗死相关性。方法以椎基底动脉MRA图像为基础构建椎基底动脉三维几何模型,分为凸透镜型正常组和凸透镜型脑梗死组,应用计算流体力学方法对椎基底动脉进行数值模拟分析。结果获得个体化椎基底动脉开窗模型的血流动力学参数,数值模拟结果包括椎基底动脉的血液速度图、血管壁切应力震荡指数(oscillatory shear index,OSI)及壁面压力(wall pressure,WP);凸透镜型脑梗死组表现为高速血流、高OSI及高WP值。结论以MRA图像为基础的数值模拟技术可以重建个体化椎基底动脉血流动力学模型,为分析其与后循环脑梗死等病变形成的关系提供研究手段;凸透镜型椎基底动脉开窗导致脑梗死可能与高速血流、高OSI及高WP值有关。

Objective To investigate the correlation between hemorheological characteristics of fenestration at the junction of vertebrobasilar artery and posterior circulation cerebral infarction.Methods Based on the MRA images of vertebrobasilar artery,a three-dimensional geometric model of vertebrobasilar artery was constructed,which was divided into cerebral infarction group and normal group.Results To obtain the hemodynamic parameters of vertebrobasilar artery models,the numerical simulation results include the blood velocity flow field of the vertebrobasilar artery,time-averaged wall shear stress(TAWSS)and wall pressure(WP);The convex lens cerebral infarction group showed high blood flow,high OSI and high WP.Conclusion The numerical simulation technology based on MRA images can reconstruct the individualized vertebrobasilar artery hemodynamic model,and provide a research method for analyzing the relationship between it and posterior circulation cerebral infarction;The cerebral infarction caused by convex lens vertebrobasilar artery fenestration may be related to high blood flow,high OSI and high WP.