山西省汾阳市老年高血压患者血清Asprosin水平与冠心病的相关性研究

Correlation Between Serum Asprosin Level and Coronary Heart Disease in Elderly Patients with Hypertension in Fenyang City,Shanxi Province

目的探讨山西省汾阳市高血压患者血清Asprosin(白脂素)水平与冠心病的相关性。方法选取2019年9月-2021年9月山西省汾阳医院住院的高血压患者119人为研究对象,依据是否有冠心病分为冠心病组(n=52)和非冠心病组(n=67)。比较两组患者的一般资料,各项体脂相关指标及血清Asprosin水平,并分析血清Asprosin水平及各项指标间的相关性。采用二元Logistic回归分析山西省汾阳市高血压患者冠心病发生的危险因素。结果冠心病组的BMI(身体质量指数),WC(腰围),HC(臀围),WHR(腰臀比),VFA(内脏脂肪面积),BF(体脂含量),PBF(体脂率),Cr(肌酐),UA(血尿酸),Asprosin,TG(甘油三酯),TC(总胆固醇)及LDL-L(低密度脂蛋白胆固醇)值高于非冠心病组。Asprosin与BMI,WC,HC,WHR,VFA,LDL-L值呈正相关。二元Logistic回归分析结果显示:BMI[OR=2.937,95%CI(1.657~4.734)],WC[OR=0.777,95%CI(0.646~0.935)],HC[OR=0.834,95%CI(0.696~1.001)],VFA[OR=2.321,95%CI(1.092~5.086)],WHR[OR=0.804,95%CI(0.676~0.957)],PBF[OR=0.859,95%CI(0.731~1.009)],UA[OR=0.992,95%CI(0.982~1.002)],Asprosin[OR=0.421,95%CI(0.153~1.158)]是山西省汾阳市高血压患者合并冠心病发生的影响因素(P<0.05)。结论Asprosin与高血压患者发生冠心病的风险密切相关。为高血压患者冠心病的预防及预后提供新的可能的治疗依据。

Objective To investigate the correlation between serum asprosin level and coronary heart disease in patients with hypertension in Lvliang area.Methods 119 patients with hypertension hospitalized in Shanxi Fenyang Hospital from September 2019 to September 2021 were selected as the research objects.They were divided into coronary heart disease group(n=52)and non coronary heart disease group(n=67)according to whether there was coronary heart disease.The general data,body fat related indexes and plasma asprosin level of the two groups were compared,and the correlation between serum asprosin level and various indexes was analyzed.Binary Logistic regression was used to analyze the risk factors of coronary heart disease in patients with hypertension in Lvliang area.Results The values of BMI(body mass index),WC(waist circumference),HC(hip circumference),WHR(waist hip ratio),VFA(visceral fat area),BF(body fat content),PBF(body fat ratio),Cr(creatinine),UA(blood uric acid),Asprosin,TG(triglyceride),TC(total cholesterol)and LDL-L(low density lipoprotein cholesterol)in coronary heart disease group were higher than those in non coronary heart disease group.Asprosin was positively correlated with BMI,WC,HC,WHR,VFA and LDL-L.Results The binary Logistic regression analysis showed that BMI[OR=2.937,95%CI(1.657~4.734)],WC[OR=0.777,95%CI(0.646~0.935)],HC[OR=0.834,95%CI(0.696~1.001)],VFA[OR=2.321,95%CI(1.092~5.086)],WHR[OR=0.804,95%CI(0.676~0.957)],PBF[OR=0.859,95%CI(0.731~1.009)]were the influencing factors of coronary heart disease in patients(OR=1.980~0.002,P<0.992).Conclusion Asprosin is closely related to the risk of coronary heart disease in patients with hypertension,to provide a new possible therapeutic basis for the prevention and prognosis of coronary heart disease in patients with hypertension.