液体活检在乳腺癌诊疗中的研究进展

Research progress of liquid biopsy in diagnosis and treatment of breast cancer

液体活检作为乳腺癌诊疗的新兴技术,主要通过无创或微创的方式对患者的血液、尿液、唾液等体液取样,检测癌性标志物用以诊断、预后评估及随访。液体活检技术对于乳腺癌的早期诊断、个体化治疗、改善预后具有重要的临床意义。该文从循环肿瘤细胞、循环肿瘤DNA、微小RNA等方面对液体活检在乳腺癌中的研究进展作一综述。

As an emerging detection technology,liquid biopsy is mainly used to take samples of patients′blood,urine,saliva and other body fluids by a non-invasive or minimally invasive way to detect cancer markers in them for diagnosis,prognosis assessment and follow-up.Liquid biopsy technique has important clinical significance for the early diagnosis,individualized treatment and improvement of prognosis of breast cancer.This paper introduces the research progress of liquid biopsy in breast cancer from the aspects of circulating tumor cells(CTCs),circulating tumor deoxyribonucleic acid(ctDNA)and micro ribonucleic acid(microRNA,miRNA).