精神分裂症快感缺失及社会认知加工缺陷的P300证据

The Relationship Between Anhedonia and Social Cognitive Processing Deficits in Schizophrenia Patients by Using P300 Component

目的 旨在利用P300成分检测精神分裂症患者快感缺失与社会认知加工缺陷的相关关系,为临床精神分裂症患者的预后及社会功能评估提供理论依据。方法 招募2019年9月—2022年8月符合DSM 5精神分裂症诊断标准的住院患者30例,及自愿参与研究的正常对照组31例。通过观看完成愉快面孔情绪图片作为靶刺激的Oddball范式,同步记录分析大脑P300成分的波幅和潜伏期。结果 与正常对照组相比,精神分裂症组所诱发的P300成分波幅降低[(2.839±0.453)uV,P <0.05],其潜伏期延长[(321.613±31.754)ms,P <0.05]。结论 精神分裂症患者存在快感缺失,在识别及加工愉快情绪面孔的能力受损,识别加工的时间更长。

Objective To detect the correlation between anhedonia and social cognitive processing deficits in patients with schizophrenia using the P300 component and provide a theoretical basis for patients’ prognosis and evaluation of social function. Methods From September 2019 to August 2022, a total of 30 inpatients who met the diagnostic criteria of DSM 5 schizophrenia and 31 normal control subjects who volunteered to participate in the study were recruited.By watching the Oddball paradigm which completed the happy face emotional picture as the target stimulus, the amplitude and latency of brain P300 component were recorded and analyzed simultaneously.Results The P300 amplitudes of patients with schizophrenia were significantly decreased [(2.839±0.453)uV, P < 0.05], and the latency was significantly longer [(321.613±31.754)ms, P < 0.05] compared with that of healthy subjects. Conclusion Schizophrenia patients have pleasure deficit, their ability to recognize and process happy emotional faces is impaired, and it takes longer to recognize and process them.