甲泼尼龙琥珀酸钠联合呼吸兴奋剂在慢性阻塞性肺疾病合并呼吸衰竭中的应用

Application of Methylprednisolone Sodium Succinate Combined With Respiratory Stimulant in COPD With Respiratory Failure

目的 探讨小剂量注射用甲泼尼龙琥珀酸钠联合呼吸兴奋剂在治疗慢性阻塞性肺疾病合并呼吸衰竭的临床效果。方法 选择2019年8月-2021年8月咸宁市第一人民医院收治的80例慢性阻塞性肺疾病合并呼吸衰竭患者作为研究对象,按随机数字表法分为观察组(40例,小剂量注射用甲泼尼龙琥珀酸钠联合呼吸兴奋剂)和对照组(40例,呼吸兴奋剂)。对比两组的动脉血气、肺功能、不良反应、临床疗效、症状改善。结果 两组治疗前的动脉血气指标、FEV_(1)/FVC、FEV_(1)、呼吸频率比较,差异无统计学意义(P>0.05);观察组治疗后的PaO_(2)、FEV_(1)/FVC、FEV_(1)高于对照组,PaCO_(2)、呼吸频率低于对照组,差异有统计学意义(P<0.05)。不良反应总发生率方面,观察组(10.00%)与对照组(2.50%)相比,差异无统计学意义(P>0.05)。总有效率方面,观察组(97.50%)高于对照组(80.00%),差异有统计学意义(P<0.05)。观察组症状改善时间均短于对照组,差异有统计学意义(P<0.05)。结论 将小剂量注射用甲泼尼龙琥珀酸钠联合呼吸兴奋剂应用到慢性阻塞性肺疾病合并呼吸衰竭患者的临床诊疗中,能促进患者肺功能的恢复,对缺氧、二氧化碳潴留等症状的改善,降低并发症发生率、提升用药疗效等均有重要意义,值得推广应用。

Objective To probe into the clinical effect of low dose methylprednisolone sodium succinate for injection combined with respiratory stimulants in treatment of chronic obstructive pulmonary disease complicated with respiratory failure.Methods From August2019 to August 2021,a total of 80 patients with chronic obstructive pulmonary disease combined with respiratory failure who were treated in Xianning First People’s Hospital were selected as the research subjects,and divided into the observation group (40 cases,low-dose methylprednisolone for injection) according to the random number table method.Nylon sodium succinate combined with respiratory stimulant) and the control group (40 cases,respiratory stimulant).Comparison of arterial blood gas,pulmonary function,adverse reactions,clinical efficacy,symptom improvement.Results There were no differences in arterial blood gas index,FEV_(1)/FVC,FEV_(1) and respiratory rate between the two groups before treatment (P>0.05).After treatment,PaO_(2),FEV_(1)/FVC and FEV_(1)in the observation group were higher than those in the control group,while PaCO_(2) and respiratory rate were lower than those in the control group,with statistical differences (P<0.05).There was no difference in the total incidence of adverse reactions between the observation group (10.00%)and the control group (2.50%)(P>0.05).In terms of total effective rate,the observation group (97.50%) was higher than the control group(80.00%),with statistical difference (P<0.05).The improvement time of symptoms in the observation group was shorter than that in the control group,with statistical difference (P<0.05).Conclusion The application of low-dose Methylprednisolone Sodium Succinate for Injection combined with respiratory stimulants in treatment of chronic obstructive pulmonary disease with respiratory failure can promote the recovery of pulmonary function,and it is great signi?cance for improving the symptoms of hypoxia,carbon dioxide retention,reducing the incidence of complications and improving the ef?cacy of drugs,thus it is worth promoting and applying.