疏肝健脾法治疗孤独症谱系障碍临床观察

Clinical Observation on the Method of Soothing Liver and Strengthening Spleen on the Treatment of Autism Spectrum Disorders

目的:基于“脑肠轴”理论观察疏肝健脾法治疗孤独症谱系障碍患儿的临床疗效。方法:筛选我院符合本次研究要求的60例孤独症谱系障碍患儿,按照随机数字表法分为治疗组和对照组,每组30例。对照组患儿接受康复教育,治疗组患儿在康复教育基础上采用疏肝健脾法口服中药结合针刺、推拿治疗。治疗3个月后由第三方评估师采用《孤独症儿童心理教育评核(第三版)》(C-PEP-3)、儿童孤独症评定量表(CARS)评定疗效。观察两组患儿不良事件发生情况。结果:与本组治疗前比较,两组患儿治疗后CARS评分均降低(P<0.01),治疗组较对照组降低更为明显(P<0.01)。两组患儿治疗后C-PEP-3评分均提高(P<0.01),治疗组较对照组提高更为明显(P<0.01)。治疗组患儿总有效率为93.33%,对照组总有效率为73.33%,治疗组疗效优于对照组(P<0.05)。除治疗组有2例患儿出现拔针后皮下淤青并自行痊愈外,其余患儿均未发生不良事件。结论:基于“脑肠轴”理论,采用疏肝健脾法治疗孤独症谱系障碍患儿的临床疗效显著,安全无不良反应。

Objective:To observe the clinical efficacy of soothing liver and strengthening spleen in the treatment of children with autism spectrum disorder based on the theory of"brain-gut axis".Methods:60 cases of children with autism spectrum disorder who met the requirements of this study in our hospital were screened and divided into the treatment group and the control group according to random number table method.In the treatment group,30 cases were treated with oral traditional Chinese medicine,acupuncture and massage combined with rehabilitation education.The control group received rehabilitation education in 30 cases.The efficacy was assessed according to scores of CARS and C-PEP-3 by a third-party evaluator after 3 months of treatment.The occurrence of adverse events in the two groups was observed.Results:The scores of CARS decreased and the scores of C-PEP-3 increased in both groups after treatment(P<0.01),and the difference was more significant in the treatment group than that in the control group(P<0.01).After treatment,the total effective rate of the two groups was 93.33%in the treatment group and 73.33%in the control group.The curative effect of the treatment group was better than that of the control group(P<0.05).In the treatment group,there were 2 cases of subcutaneous bruising after needle removal and they recovered by themselves,while the other children had no adverse events.Conclusion:Based on the theory of"brain-gut axis",the method of soothing liver and strengthening spleen on the treatment of children with autism spectrum disorder has significant clinical efficacy,safety and no side effects.