重复经颅磁刺激联合草酸艾司西酞普兰治疗女性更年期抑郁症的临床疗效分析

Clinical efficacy analysis of repeated transcranial magnetic stimulation combined with escitalopram oxalate in the treatment of female menopausal depression

目的探讨重复经颅磁刺激(rTMS)联合草酸艾司西酞普兰治疗女性更年期抑郁症患者的效果。方法选择40例女性更年期抑郁症患者,根据治疗方式不同分为观察组与对照组,每组20例。观察组实施rTMS联合草酸艾司西酞普兰治疗,对照组实施草酸艾司西酞普兰联合伪刺激治疗。比较治疗前后两组患者睡眠质量、抑郁情绪与认知功能。结果治疗前,两组睡眠质量评分比较,差异无统计学意义(P>0.05);治疗后,观察组睡眠质量各项评分均低于对照组,差异有统计学意义(P<0.05)。治疗前,两组认知功能评分比较,差异无统计学意义(P>0.05);治疗后,观察组认知功能各项评分均优于对照组,差异有统计学意义(P<0.05)。治疗前,两组抑郁评分比较,差异无统计学意义(P>0.05);治疗后,观察组抑郁评分低于对照组,差异有统计学意义(P<0.05)。结论女性更年期抑郁症患者采用rTMS联合草酸艾司西酞普兰治疗,可以有效改善患者抑郁情绪和睡眠质量,提高其认知功能,值得临床推广与应用。

Objective To investigate the effect of repeated transcranial magnetic stimulation(rTMS) combined with Escitalopram oxalate in the treatment of female menopausal depression. Methods A total of 40 female patients with menopausal depression were selected and divided into observation group and control group according to different treatment methods, with 20cases in each group. The observation group was treated with rTMS combined with Escitalopram oxalate, and the control group was treated with Escitalopram oxalate combined with pseudo stimulation. Sleep quality, depressive mood and cognitive function were compared between the two groups before and after treatment. Results Before treatment, there was no significant difference in sleep quality scores between the two groups(P>0.05). After treatment, the sleep quality scores of the observation group were lower than those of the control group, and the difference was statistically significant(P<0.05). Before treatment, there was no significant difference in cognitive function scores between the two groups(P>0.05). After treatment, the cognitive function scores of the observation group were better than those of the control group, and the difference was statistically significant(P<0.05). Before treatment, there was no significant difference in depression scores between the two groups(P>0.05). After treatment, the depression score of the observation group was lower than that of the control group, and the difference was statistically significant(P<0.05).Conclusion rTMS combined with Escitalopram oxalate can effectively improve depressive mood, sleep quality and cognitive function in female menopausal patients with depression, which is worthy of clinical promotion and application.