比索洛尔联合胺碘酮治疗心律失常的疗效及对老年患者心功能、hs-CRP的影响分析

Analysis of efficacy of bisoprolol combined with amiodarone on arrhythmia and its influence on cardiac function and hs-CRP in elderly patients

目的研究比索洛尔联合胺碘酮治疗心律失常的疗效及对老年患者心功能、超敏C反应蛋白(hs-CRP)的影响。方法88例老年心律失常患者,按照入院编号的奇偶性分为研究组与对照组,各44例。对照组单用胺碘酮治疗,研究组应用比索洛尔联合胺碘酮治疗。比较两组治疗效果及治疗前后心功能指标、hs-CRP水平。结果研究组治疗总有效率为97.73%,高于对照组的72.73%,差异有统计学意义(P<0.05)。治疗后,研究组左室收缩末期内径(LVESD)(25.74±3.62)mm、左室舒张末期内径(LVEDD)(37.06±3.75)mm小于对照组的(28.57±3.85)、(40.64±3.81)mm,左室射血分数(LVEF)(58.26±5.38)%大于对照组的(55.31±5.42)%,差异有统计学意义(P<0.05)。治疗后,两组hs-CRP水平均较治疗前改善,且研究组hs-CRP(8.56±2.15)mg/L低于对照组的(13.94±3.08)mg/L,差异有统计学意义(P<0.05)。结论比索洛尔联合胺碘酮治疗心律失常疗效确切,老年患者的心功能得到显著改善,hs-CRP水平明显下降,值得临床推广与应用。

Objective To study the efficacy of bisoprolol combined with amiodarone on arrhythmia and its influence on cardiac function and high-sensitivity C-reactive protein(hs-CRP)in elderly patients.Methods A total of 88 elderly patients with arrhythmias were divided into a research group and a control group according to the parity of admission numbers,with 44 cases in each group.The control group was treated with amiodarone alone,and the research group was treated with bisoprolol combined with amiodarone.The therapeutic effect,cardiac function index and hs-CRP level before and after treatment were compared between the two groups.Results The total effective rate of treatment was 97.73%in the research group,which was higher than 72.73%in the control group,and the difference was statistically significant(P<0.05).After treatment,the left ventricular end-systolic diameter(LVESD)(25.74±3.62)mm and left ventricular end-diastolic diameter(LVEDD)(37.06±3.75)mm in the research group were smaller than(28.57±3.85)and(40.64±3.81)mm in the control group,the left heart ejection fraction(LVEF)(58.26±5.38)%in the research group was greater than(55.31±5.42)%in the control group;the difference was statistically significant(P<0.05).After treatment,the hs-CRP levels in both groups were better than those before treatment,and hs-CRP(8.56±2.15)mg/L in the research group was lower than(13.94±3.08)mg/L in the control group,and the difference was statistically significant(P<0.05).Conclusion Bisoprolol combined with amiodarone has a definite efficacy on arrhythmia,and can significantly improve the cardiac function of the elderly patients and reduce the level of hs-CRP,which is worth clinical promotion and application.