苄星青霉素治疗早期梅毒的效果分析

Analysis of the effect of benzathine penicillin in the treatment of early syphilis

目的观察苄星青霉素治疗早期梅毒的疗效。方法48例早期梅毒患者,按照随机原则分为对照组和试验组,每组24例。对照组患者采用阿奇霉素治疗,试验组患者采用苄星青霉素治疗。比较两组患者临床疗效、不良反应发生情况及治疗前后T细胞亚群相关指标。结果试验组患者治疗总有效率为95.83%,高于对照组的66.67%,差异具有统计学意义(P<0.05)。治疗后,两组患者CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)高于本组治疗前,CD8^(+)低于本组治疗前,且试验组患者CD3^(+)(69.24±3.47)%、CD4^(+)(44.47±2.23)%、CD4^(+)/CD8^(+)(1.76±0.24)高于对照组的(65.14±5.27)%、(37.57±4.60)%、(1.28±0.35),CD8^(+)(25.21±5.17)%低于对照组的(29.26±4.65)%,差异具有统计学意义(P<0.05)。两组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论早期梅毒患者采用苄星青霉素治疗效果明显,能有效改善机体免疫功能,进而更好的控制病情,且药物不良反应较少,值得临床推广应用。

Objective To observe the efficacy of benzathine penicillin in the treatment of early syphilis.Methods A total of 48 patients with early syphilis were randomly divided into a control group and a experimental group,with 24 cases in each group.Patients in the control group were treated with azithromycin,and patients in the experimental group were treated with benzathine penicillin.The clinical efficacy,occurrence of adverse reactions and the indexes related to T-cell subsets before and after treatment were compared between the two groups.Results The total effective rate of treatment in the experimental group was 95.83%,which was higher than 66.67%in the control group,and the difference was statistically significant(P<0.05).After treatment,the CD3^(+),CD4^(+),CD4^(+)/CD8^(+)in both groups were higher than those before treatment in this group,and CD8^(+)was lower than that before treatment in this group;the CD3^(+)(69.24±3.47)%,CD4^(+)(44.47±2.23)%,CD4^(+)/CD8^(+)(1.76±0.24)in the experimental group were higher than(65.14±5.27)%,(37.57±4.60)%,(1.28±0.35)in the control group;CD8^(+)(25.21±5.17)%in the experimental group was lower than(29.26±4.65)%in the control group;the differences were all statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Benzathine penicillin shows obvious effect on patients with early syphilis,and can effectively improve the immune function of the body,and then better control the disease with less adverse drug reactions,which is worthy of clinical promotion and application.