四逆晕痛汤治疗后循环缺血性眩晕经气不利证随机对照研究

Sini Yuntong Decoction in treating posterior circulation ischemic vertigo of inhibited flow of meridian qi syndrome:A randomized controlled trial

目的观察四逆晕痛汤对后循环缺血性眩晕(PCIV)经气不利证患者的治疗效果。方法将150例PCIV经气不利证患者按照随机数字表法分为2组,对照组75例予常规西药治疗,治疗组75例在对照组治疗基础上予四逆晕痛汤口服,2组均治疗14 d。比较2组治疗前后欧洲眩晕评估量表(EEV)评分、眩晕等级评定量表(DARS)评分、中医证候评分及左椎动脉(LVA)、右椎动脉(RVA)、基底动脉(BA)的平均血流速度(Vm),并统计2组疗效。结果治疗组总有效率90.7%(68/75),对照组总有效率81.3%(61/75),治疗组疗效优于对照组(P<0.05)。2组治疗后EEV、DARS评分均较本组治疗前降低(P<0.05),且治疗组治疗后均低于对照组(P<0.05)。2组治疗后中医证候各项评分及总分均较本组治疗前降低(P<0.05),且治疗组治疗后头晕目眩、视物旋转、恶心呕吐、耳鸣评分及总分均低于对照组(P<0.05)。2组治疗后LVA、RVA、BA Vm均较本组治疗前升高(P<0.05),且治疗组治疗后LVA、RVA Vm均高于对照组(P<0.05)。结论四逆晕痛汤对PCIV经气不利证患者眩晕及其伴随症状具有良好的缓解作用,可有效改善后循环供血,无不良反应,值得临床应用。

Objective To observe the therapeutic effect of Sini Yuntong Decoction in treating posterior circulation ischemic vertigo(PCIV)of inhibited flow of meridian qi syndrome.Methods A total of 150 PCIV patients(inhibited flow of meridian qi syndrome)were randomly 1:1 assigned to treat with conventional Western medicine(the control group)or Sini Yuntong Decoction+conventional Western medicine(the treatment group)for 14 days.The aiming was to compare the European Evaluation of Vertigo scale(EEV),the dizziness assessment rating scale(DARS),traditional Chinese medicine(TCM)syndrome score,mean blood velocity(Vm)of left vertebral artery(LVA),right vertebral artery(RVA),basilar artery(BA);the curative effect was assessed.Results The overall effective rate in the treatment group was better than that in the control group(90.7%[68/75]vs 81.3%[61/75],[P<0.05],respectively).After treatment,EEV,DARS in the both groups were decreased(P<0.05),which were decreased in the treatment group compared with the control group(P<0.05);TCM symptom scores in the both groups were decreased(P<0.05),TCM symptom(dizziness,visual rotation,nausea,vomiting,tinnitus)scores were lower in the treatment group than in the control group(P<0.05);Vm of LVA,RVA,BA in the both groups were increased(P<0.05),Vm of LVA,RVA were higher in the treatment group than in the control group(P<0.05).Conclusion For PCIV patients(inhibited flow of meridian qi syndrome),Sini Yuntong Decoction can relieve vertigo and its associated symptoms well,which can effectively improve blood supply in the posterior circulation,with no adverse reactions,and worthy of clinical application.