活血化瘀汤在急性心肌梗死经皮冠状动脉介入治疗术后的运用效果

Effect of Huoxue Huayu Decoction in the treatment of Acute Myocardial Infarction After percutaneous coronary intervention

目的研究活血化瘀汤在急性心肌梗死(AMI)经皮冠状动脉介入治疗(PCI)术后的应用效果。方法选择80例AMI PCI术后患者作为研究对象,按照随机数字表法分为2组。对照组40例予常规西药治疗,治疗组40例在对照组的基础上加用活血化瘀汤治疗,均治疗4周后统计临床疗效,比较2组术后当日及治疗后血清脑利钠肽(BNP)、细胞间黏附分子-1(ICAM-1)、C反应蛋白(CRP)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)水平及左心室舒张末期容积(LVEDV)、左心室收缩末期容积(LVESV)、左室射血分数(LVEF)、中医证候评分变化。结果治疗组总有效率92.5%(37/40),对照组总有效率75.0%(30/40),治疗组总有效率显著高于对照组(P<0.05)。治疗后,2组BNP、ICAM-1、IL-6、CRP、TNF-α水平及LVEDV、LVESV、各项中医证候评分和总分均较本组术后当日明显下降(P<0.05),且治疗组均低于对照组(P<0.05)。治疗后,2组LVEF均较本组术后当日明显升高(P<0.05),且治疗组显著高于对照组(P<0.05)。结论活血化瘀汤可显著改善AMI患者PCI术后临床症状,减轻心肌损伤程度,提高心功能,提高临床疗效。

Objective To study the effect of Huoxue Huayu Decoction in the treatment of acute myocardial infarction(AMI)after percutaneous coronary intervention(PCI).Methods AMI patients(n=80)underwent PCI in our hospital from November 2019 to September 2021 were randomly in a 1:1 ratio to receive either Western medicine(the control group)or Huoxue Huayu Decoction+Western medicine(the study group)for 4 weeks.The key observation was clinical efficacy,serum brain natriuretic peptide(BNP),intercellular adhesion molecule-1(ICAM-1),C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),left ventricular end-diastolic volume(LVEDV),left ventricular end-systolic volume(LVESV),left ventricular ejection fraction(LVEF),traditional Chinese medicine(TCM)syndrome score.Results The total effective rate in the study group was significantly higher than that in the control group(92.5%[37/40]vs 75.0%[30/40];[P<0.05],respectively).After treatment,the score and total scores of BNP,ICAM-1,IL-6,CRP,TNF-α,LVEDV,LVESV,TCM in groups were significantly lower than those in the same-day following PCI(P<0.05),and which in study group were prevalence(P<0.05);but LVEF level was significantly higher in two groups(P<0.05),and the study group was common(P<0.05).Conclusion For AMI patients after PCI,Huoxue Huayu Decoction is capable relieving clinical symptoms,reducing the degree of myocardial injury,improving their cardiac function,with significant clinical efficacy.