基于网络药理学探讨马针颗粒治疗仔猪腹泻的作用机制

To Explore the Mechanism of Ma Zhen Granule in the Treatment of Piglet Diarrhea Based on Network Pharmacology

基于网络药理学方法,利用TCMSP、Drugbank、STRING、DAVID、BIOGPS等数据库分析马针颗粒的重要化合物、靶点、调控通路与归经,探讨马针颗粒治疗仔猪腹泻的作用机制。结果显示,马针颗粒通过异甜菜甙、异甜菜素、花生四烯酸、β-胡萝卜素、槲皮素作用TP53、TNF、JUN、CASP3等靶点调节炎症、免疫来改善仔猪腹泻。

Based on network pharmacology method,the important compounds,targets,regulatory pathways and meridians of Ma Zhen granule were analyzed by using TCMSP,Drugbank,STRING,DAVID,BIOGPS and other databases,to explore the action mechanism of Ma Zhen granule in the treatment of piglet diarrhea.The results showed that the effect of Ma Zhen granule on piglets diarrhea is related to isobetanin_qt,isobetanidin,arachidonic acid,beta-carotene and quercetin regulating inflammation and immunity by the targets of TP53,TNF,JUN,CASP3 and so on.