1990-2019年我国多发性骨髓瘤疾病负担及其变化趋势分析

Analysis of the Burden of Multiple Myeloma and its Changing Trend in China from 1990 to 2019

目的分析1990-2019年我国多发性骨髓瘤(MM)的疾病负担及变化趋势,旨在为多发性骨髓瘤疾病的防控提供科学、有效的依据。方法提取2019年全球疾病负担数据库(GBD2019)中的我国部分数据及全球数据,采用发病率、死亡率、伤残损失健康寿命年(YLDs)、早死损失寿命年(YLLs)、伤残调整寿命年(DALYs)进行描述,利用Joinpoint回归模型分析多发性骨髓瘤的标化发病率、标化死亡率、标化YLDs率、标化YLLs率和标化DALYs率的平均年度百分比变化率(AAPC),以及多发性骨髓瘤的疾病负担、变化趋势。结果2019年,我国多发性骨髓瘤病例数为18793例,发病率为1.32/10万;死亡病例13422例,死亡率为0.94/10万;DALYs为347453例,DALYs率为24.43/10万;与1990年相比,2019年多发性骨髓瘤的发病率、死亡率及DALYs率变化率为2.38%、0.92%及0.95%。男性的发病率、死亡率、DALYs率均高于女性,且随年龄增长均呈上升趋势;1990-2019年,我国多发性骨髓瘤标化发病率(AAPC=1.00,P<0.05)、标化死亡率(AAPC=0.16,P<0.05)和标化DALYs率(AAPC=0.21,P<0.05)均呈上升趋势。结论1990-2019年,我国多发性骨髓瘤疾病负担趋势升高,涨幅高于全球数据水平。

Objective To analyze the disease burden and change trend of multiple myeloma(MM)in China from 1990 to 2019,so as to provide scientific and effective basis for the prevention and control of multiple myeloma.Methods China's data and global data in the Global Burden of Disease Database 2019(GBD2019)were extracted.Morbidity,mortality,years of life lost due to disability(YLDs),years of life lost due to premature death(YLLs),and disability adjusted life years(DALYs)were used for description.The Joinpoint regression model was used to analyze the average annual percentage change rate(AAPC)of the standardized incidence rate,standardized mortality rate,standardized YLDs rate,standardized YLLs rate and standardized DALYs rate of multiple myeloma,as well as the disease burden and changing trend of multiple myeloma.Results In 2019,there were 18793 cases of multiple myeloma in China,with an incidence of 1.32/100000.There were 13422 deaths,with a mortality rate of 0.94/100000.The number of DALYs was 347453,and the DALYs rate was 24.43/100000.Compared with 1990,the incidence,mortality and DALYs rate of multiple myeloma in 2019 were 2.38%,0.92%and 0.95%,respectively.The morbidity,mortality and DALYs rate of male were higher than those of female,and increased with age.From 1990 to 2019,the standardized incidence rate(AAPC=1.00,P<0.05),standardized mortality rate(AAPC=0.16,P<0.05)and standardized DALYs rate(AAPC=0.21,P<0.05)of multiple myeloma in China showed an upward trend.Conclusion From 1990 to 2019,the disease burden of multiple myeloma in China has increased,and the differences between different genders and ages are statistically significant,the increase rate is higher than the global data level.