基于中医传承辅助平台总结当代医家治疗食管癌血瘀痰滞证的用药规律

Summary of Medication Rules of Contemporary Doctors in Treating Esophageal Cancer of Blood Stasis and Phlegm Stagnation Syndrome Based on Traditional Chinese Medicine Inheritance Support System

目的收集整理当代医家治疗食管癌血瘀痰滞证的诊疗信息,探索中医治疗食管癌血瘀痰滞证的用药规律,为食管癌的治疗提供依据及临床研发新药提供参考。方法收集1992年1月-2022年1月中国期刊网全文数据库(CNKI)中有关中医治疗食管癌血瘀痰滞证的相关文献,基于中医传承辅助平台软件建立相应的数据库,通过频次统计、组方规律、新方分析等,探索当代中医治疗食管癌的常用药物、配伍规则、核心药物组合及挖掘中药新方。结果共纳入53个方剂,得到治疗血瘀痰滞证中药175味,使用频次≥5的药物有59味,其中常用药物排名前5的分别为半夏、白术、茯苓、甘草、威灵仙;用药模式共36条,其中出现最高频次为16,分别为:白术、茯苓、半夏、代赭石;常用药物规则共36条,置信度最高的分别为:白花蛇舌草->半夏;旋覆花->代赭石;核心药物网络展示共21味药,得出11个新方组合。结论益气健脾、理气化痰、化瘀散结为治疗食管癌血瘀痰滞证的主要方法,这些方法标本兼施,对本病的临床治疗及组方用药具有重要价值。

Objective To collect and sort out the diagnosis and treatment information of contemporary doctors in the treatment of esophageal cancer with blood stasis and phlegm stagnation syndrome,and to explore the medication rules of traditional Chinese medicine in the treatment of esophageal cancer with blood stasis and phlegm stagnation syndrome,so as to provide basis for the treatment of esophageal cancer and provide reference for clinical research and development of new drugs.Methods The relevant literatures on the treatment of esophageal cancer with blood stasis and phlegm stagnation syndrome by traditional Chinese medicine in CNKI from January 1992 to January 2022 were collected,and the corresponding database was established based on the software of traditional Chinese medicine inheritance auxiliary platform.Through frequency statistics,prescription rules,new prescription analysis,etc.,the common drugs,compatibility rules,core drug combinations and new prescriptions of traditional Chinese medicine for the treatment of esophageal cancer were explored.Results A total of 53 prescriptions were included,and 175 Chinese medicines for the treatment of blood stasis and phlegm stagnation syndrome were obtained,while 59 medicines were used more than 5 times.Among them,the top 5 commonly used medicines were Pinellia pinellia,Atractylodes atractylodes,Poria cocos,Licorice licorice,and Willebrand.A total of 36 drug patterns were obtained,among which the highest frequency was 16,which were Atractylodes atractylodes,Poria cocos,Pinellia pinellia and substituted ochre.A total of 36 common drug rules were analyzed,and the highest confidence was:Hedyotis alba->Pinellia pinellia;Napus->substitute ochre.The core drug network showed a total of 21 drugs and obtained 11 new prescription combinations.Conclusion Nourishing qi to invigorate spleen,regulating qi and resolving phlegm,removing blood stasis and dissipating mass are the main methods for the treatment of esophageal cancer with blood stasis and phlegm stagnation syndrome.These methods are of great value to the clinical treatment and prescription of this disease.