罗浮山风湿膏药外敷联合秋水仙碱片内服对急性痛风性关节炎患者血尿酸水平及促炎因子的影响

Effect of external application of Luofu Shan rheumatism plaster combined with colchicine tablets on serum uric acid level and proinflammatory factors in patients with acute gouty arthritis

目的:对急性痛风性关节炎(AGA)患者采用外敷罗浮山风湿膏药联合内服秋水仙碱片治疗,观察其血尿酸(BUA)水平变化及对患者促炎因子的影响。方法:选择96例AGA患者,采用随机数字表法分为对照组及观察组,每组48例。两组均口服常规剂量秋水仙碱片,观察组联合外敷罗浮山风湿膏药。两组均治疗2周后,评价其临床疗效,比较两组治疗前后关节疼痛、关节功能评分,检测BUA、C反应蛋白(CRP)及血清白细胞介素1β(IL-1β)、白细胞介素6(IL-6)水平,记录不良反应发生情况。结果:观察组总有效率95.83%明显高于对照组的83.33%(P<0.05);治疗后观察组关节疼痛及功能评分均明显低于对照组(P<0.05);治疗后观察组BUA、CRP、IL-1β、IL-6水平均明显低于对照组(P<0.05);观察组不良反应发生率22.92%明显低于对照组的47.92%(P<0.05)。结论:外敷罗浮山风湿膏药联合内服秋水仙碱片治疗AGA患者临床疗效更为理想,可有效降低患者BUA及各促炎因子水平,改善其关节功能及关节疼痛症状,并减少不良反应发生情况。

Objective:To observe the change of serum uric acid(BUA)level and its influence on proinflammatory factors in patients with acute gouty arthritis(AGA)by applying Luofu Shan rheumatism plaster externally and taking colchicine tablets internally.Methods:96 patients with AGA were selected and divided into control group and observation group by random number table method,48 cases in each group.Both groups received conventional oral colchicine tablets,and the observation group combined with external application of Luofu Shan rheumatism plaster.After 2 weeks of treatment,the clinical efficacy of the two groups was evaluated,joint pain and joint function scores were compared before and after treatment,BUA,C-reactive protein(CRP)and serum interleukin 1β(IL-1β)and interleukin 6(IL-6)levels were detected,and the incidence of adverse reactions was recorded.Results:The total effective rate of observation group was 95.83%significantly higher than that of control group 83.33%(P<0.05).After treatment,the joint pain and functional scores in the observation group were significantly lower than those in the control group(P<0.05).After treatment,BUA,CRP,IL-1βand IL-6 levels in observation group were significantly lower than those in control group(P<0.05).The incidence of adverse reactions in observation group was 22.92%significantly lower than 47.92%in control group(P<0.05).Conclusion:External application of Luofu Shan rheumatic plaster combined with internal administration of colchicine tablets has more ideal clinical efficacy in the treatment of AGA patients,which can effectively reduce the levels of BUA and pro-inflammatory factors,improve joint function and joint pain symptoms,and reduce the incidence of adverse reactions.