盐酸米诺环素软膏联合聚维酮碘含漱液治疗正畸者重度牙周炎的疗效分析

Analysis of effect of minocycline hydrochloride ointment combined with povidone-iodine gargle in the treatment of severe periodontitis in orthodontic patients

目的分析盐酸米诺环素软膏联合聚维酮碘含漱液治疗正畸者重度牙周炎的疗效。方法选取2020年2月至2021年12月在秦皇岛市海港医院进行正畸的重度牙周炎患者,按照随机数字表法分为对照组和观察组。其中对照组使用聚维酮碘含漱液进行治疗,观察组在对照组的基础上使用盐酸米诺环素软膏进行治疗。观察两组患者的炎症因子表达水平、氧化应激指标、免疫功能指标、牙周指标、视觉模拟评分(VAS)、不良反应发生情况。结果共纳入患者80例,对照组与观察组各40例。与治疗前相比,治疗后两组患者的肿瘤坏死因子α、白细胞介素1β、白细胞介素6、丙二醛、CD_(4)^(+)、CD_(4)^(+)/CD_(8)^(+)、牙周袋深度、龈沟出血指数、牙齿菌斑指数、牙龈指数、牙齿松动度、附着水平丧失、VAS评分等指标水平均降低,白细胞介素10、超氧化物歧化酶、谷胱甘肽过氧化物酶、CD_(8)^(+)水平升高,且观察组治疗前后变化幅度较大,差异具有统计学意义(P<0.05)。观察组的临床疗效优于对照组,差异具有统计学意义(P<0.05)。结论米诺环素软膏联合聚维酮碘含漱液治疗可有效消除炎症,提升免疫功能,使牙周指标趋于正常。

Objective To analyze the effect of minocycline hydrochloride ointment combined with povidone-iodine gar⁃gle on periodontal indexes in orthodontic patients.Methods Orthodontic patients with periodontitis diagnosed and treated in Qinhuangdao Haigang Hospital from February 2020 to December 2021 were selected,and divided into control group and ob⁃servation group according to random number table.The control group was treated with povidone-iodine gargle,and the obser⁃vation group was treated with minocycline hydrochloride ointment on the basis of the control group.The expression levels of inflammatory factors,oxidative stress indexes,immune function indexes,periodontal indexes,visual analogue score(VAS),and adverse reactions were detected and observed in the two groups.Results A total of 80 patients were included,with 40 cases in each group.Compared with the pre-treatment,tumor necrosis factorα,interleukin 1β,interleukin 6,malondialde⁃hyde,CD_(4)^(+),CD_(4)^(+)/CD_(8)^(+),periodontal pocket depth,sulcus bleeding index,dental plaque index,gingival index,tooth mobili⁃ty,loss of attachment level,VAS scores were decreased,interleukin 10,superoxide dismutase,glutathione peroxidase and CD_(8)^(+) were increased with statistical differences(P<0.05),and the changes in the observation group were more obvious.Com⁃pared with the control group,the clinical efficacy of the observation group was better with a statistical difference(P<0.05).Conclusion Minocycline ointment combined with povidone-iodine gargle can effectively eliminate inflammation,improve immune function,and make the periodontal indexes normalize,and the curative effect is remarkable.