加强帕金森病消化道症状的管理和研究

Focusing on new research and clinical management of gastrointestinal symptoms in Parkinson′s disease

消化道症状是帕金森病常见的非运动症状, 贯穿疾病全程, 与帕金森病的发生发展有着密切关系:如便秘可以是帕金森病前驱期重要症状, 胃轻瘫可对药代动力学产生不利作用, 进而减弱药物疗效。但目前对帕金森病消化道症状的关注及研究较少, 对其早期识别、诊断及管理没有统一规范的推荐, 消化道症状也严重影响了患者生活质量。而针对肠脑轴、胃肠道屏障、胃肠道微生物的研究和干预有可能在改善消化道症状和延缓疾病进程中起到积极作用。

Gastrointestinal symptoms are common nonmotor symptoms of Parkinson′s disease,which are related closely to occurrence and progress of Parkinson′s disease,as well as throughout its whole process.For example,constipation can be an important symptom in prodromal stage of Parkinson′s disease,and gastroparesis would weaken the effect of drug by interfering pharmacokinetics.However,insufficient attention has been paid to the gastrointestinal symptoms of Parkinson′s disease presently,and there are few effective treatments,which compromise the quality of patients′life greatly.The intervention focus on gut-brain axis,microbiota and gastrointestinal barrier may play a positive role in improving gastrointestinal symptoms and delaying the process of Parkinson′s disease.