永康市13463例女性HPV感染情况及基因型分析

Analysis of HPV infection and genotype in 13463 female patients in Yongkang City

目的探讨永康地区女性人乳头瘤病毒(HPV)的感染情况和基因亚型分布特征。方法回顾性分析2019年1月—2021年12月就诊于本院门诊的13463例HPV检测样本,应用DNA杂交技术对待测样本进行24种HPV基因亚型检测。结果永康地区女性患者阳性率为15.06%(2027/13463),以单重高危型感染为主,占比为10.14%(1365/13463),优势型别为HPV52和HPV16亚型;多重感染以高危型双重感染为主,双重感染基因亚型组合形式有87种,三重及以上基因亚型感染组合形式有66种;女性各年龄阶段阳性率差异有统计学意义(P<0.01)。结论永康市女性HPV感染基因亚型具有地域性差异的特点,不同年龄阶段HPV感染率随着年龄分布呈U型,目前上市疫苗不能完全涵盖保护永康市大部分多重感染患者基因亚型。希望本文研究可以为本地区女性预防HPV感染及疫苗选择提供一定数据依据。

Objective To investigate the infection and gene subtype distribution of female human papillomavirus(HPV)in Yongkang area.Methods A total of 13463 HPV samples from the outpatient department of our hospital from January 2019 to December 2021 were retrospectively analyzed,and 24 HPV gene subtypes were detected by DNA hybridization.Results The positive rate of female patients in Yongkang area was 15.06%(2027/13463),and single high-risk type was dominant,accounting for 10.14%(1365/13463).The dominant type was HPV52 and HPV16 subtypes.There were 87 types of double infection gene subtypes,and 66 types of triple or more gene subtypes.There was statistical significance on the differences in positive rate among different age groups(P<0.01).Conclusion There are regional differences in HPV infection gene subtypes in female patients in Yongkang City.HPV infection rate at different age stages presents U-shaped distribution with age distribution.The present vaccines on the market cannot fully cover the protection of most of the genetic subtypes of multiple infection patients in Yongkang City.This study is expected to provide some data basis for women in this area to prevent HPV infection and vaccine selection.