调髓促醒针法联合单唾液酸四己糖神经节苷酯治疗重度颅脑损伤昏迷的效果观察

Observation on the Effect of Marrow Regulating and Wakening Promoting Acupuncture Combined with Tetrahexose Ganglioside Monosialate in the Treatment of Coma after Severe Craniocerebral Injury

目的探讨调髓促醒针法联合四己糖神经节苷酯治疗重度颅脑损伤昏迷的临床效果。方法选取2019年2月—2021年2月在医院确诊的56例重度颅脑损伤昏迷患者,采用随机数字表法将患者分为观察组和对照组各28例。对照组采用普通针刺+单唾液酸四己糖神经节苷酯治疗,观察组采用调髓促醒针法+单唾液四己糖神经节苷酯治疗,均持续治疗1个月。评估两组临床疗效;治疗前后,采用格拉斯哥昏迷指数评分(GCS)评估两组患者的昏迷程度;比较两组神经元特异性烯醇化酶(NSE)、星形胶质源性蛋白(S100β)及泛素羧基末端水解酶L1(UCH-L1)水平。结果观察组总有效率为96.43%,与对照组的82.14%比较,差异无统计学意义(P>0.05);在治疗14 d及1个月后,观察组GCS评分均高于对照组(P<0.05);观察组NSE、S100β及UCH-L1水平均显著低于对照组(P<0.05)。结论调髓促醒针法联合单唾液酸四己糖神经节苷酯治疗重度颅脑损伤昏迷的临床疗效较好,可减轻神经损伤程度,促进快速苏醒。

Objective To explore the clinical effect of marrow regulating and awakening promoting acupuncture combined with tetrahexose ganglioside in the treatment of coma after severe craniocerebral injury.Methods 56 comatose patients with severe craniocerebral injury diagnosed in our hospital from February 2019 to February 2021 were randomly divided into observation group and control group,with 28 cases in each group.The control group was treated with ordinary acupuncture+tetrahexose ganglioside monosialate,and the observation group was treated with marrow regulating and awakening promoting acupuncture+tetrahexose ganglioside for 1 month.Evaluate the clinical efficacy of the two groups;Before and after treatment,the coma degree of the two groups was evaluated by Glasgow Coma index score(GCS);Neuron specific enolase(NSE)and astrocyte derived protein(S100)were compared between the two groupsβ)And ubiquitin carboxyl terminal hydrolase L1(UCH-L1).Results The total effective rate of the observation group was 96.43%,which had no significant difference compared with 82.14%of the control group(P>0.05);after 14 days and 1 month of treatment,the GCS scores of the observation group were higher than those of the control group(P<0.05);NSE and S100 in the observation groupβAnd UCH-L1 levels were significantly lower than those in the control group(P<0.05).Conclusion The method of regulating marrow and promoting wakefulness combined with tetrahexose ganglioside monosialate is effective in the treatment of coma after severe craniocerebral injury.It can reduce the degree of nerve injury and promote the rapid recovery of patients.