生脉复律汤辅助治疗非ST段抬高型心肌梗死并室性早搏的疗效及对动态心电图指标、血清NF-κB、IL-6水平的影响

Effect of Shengmai Fulyu Decoction(生脉复律汤) in Auxiliary Treatment of Non-ST SegmentE levation Myocardial Infarction Combined with Ventricular Premature Beat and Its Influences on Dynamic Electrocardiogram Indexes,Serum Levels of NF-κB and IL-6

目的 探讨生脉复律汤辅助治疗非ST段抬高型心肌梗死(NSTEMI)并室性早搏(VPB)的疗效及对动态心电图指标、血清核因子κB(NF-κB)、白细胞介素-6(IL-6)、肌钙蛋白I(cTnI)水平的影响。方法 2020年4月—2021年4月在医院确诊的80例NSTEMI并VPB气阴两虚证患者,采用简单随机分组将所有纳入患者分为观察组40例和对照组40例。对照组给予盐酸胺碘酮片治疗,观察组在对照组的基础上给予生脉复律汤辅助治疗。治疗1个月后,分析比较两组患者临床治疗效果,比较治疗前后动态心电图指标[全部正常R-R间期标准差(SDNN)、每5 min R-R间期的标准差(SDANNI)、正常相邻R-R间期差值的均方根(rMSSD)、正常相邻R-R间期差值>50 ms的百分比(PNN50)]、中医证候评分、血清NF-κB、IL-6、cTnI水平差异,并记录治疗期间两组患者不良反应发生情况。结果 治疗后观察组患者临床治疗有效率显著高于对照组(P<0.05);治疗后两组患者的中医证候评分、动态心电图指标、血清NF-κB、IL-6、cTnI水平均减少程度明显优于对照组(P<0.05);观察组患者治疗过程中不良反应发生率为明显低于对照组(P<0.05)。结论 生脉复律汤辅助辅助治疗NSTEMI并VPB气阴两虚证患者有显著的治疗效果,能通过改善患者体内炎症微环境,修复患者心肌损伤,改善患者的心脏功能,且能有效降低不良反应。

Objective To explore the effect of Shengmai Fulyu Decoction(生脉复律汤)in the auxiliary treatment of non-ST segment elevation myocardial infarction(NSTEMI)combined with ventricular premature beat(VPB)and its influences on dynamic electrocardiogram(ECG)indexes,serum levels of nuclear factor kappa-B(NF-κB),interleukin-6(IL-6)and cardiac troponin I(cTnI).Methods A total of 80 patients confirmed with NSTEMI and VPB of Qi-Yin deficiency syndrome in the hospital were enrolled between April 2020 and April 2021.According to simple random grouping method,they were divided into observation group(40 cases)and control group(40 cases).The control group was treated with amiodarone hydrochloride tablets,while the observation group was additionally treated with Shengmai Fulyu Decoction.After 1 month of treatment,the clinical curative effect was analyzed and compared between the two groups.The differences in dynamic ECG indexes[standard deviation of all normal-to-normal intervals(SDNN),standard deviation of the average all normal-to-normal intervals(SDANNI),root mean square of differences between adjacent normal-to-normal intervals/root mean square differences of successive R-R(rMSSD),percent of NN50 in the total number of normal-to-normal intervals(PNN50)],scores of TCM syndromes,serum levels of NF-κB,IL-6 and cTnI before and after treatment were compared.The occurrence of adverse reactions during treatment in both groups was recorded.Results After treatment,the response rate of clinical treatment in the observation group was significantly higher than that in the control group(P<0.05).After treatment,the decrease in the scores of TCM syndromes,dynamic ECG indexes,serum levels of NF-κB,IL-6 and cTnI in the observation group was significantly better than that in the control group(P<0.05),and the incidence of adverse reactions during treatment was significantly lower than that in the control group(P<0.05).Conclusion The curative effect of Shengmai Fulyu Decoction is significant on patients with NSTEMI and VPB of Qi-Yin deficiency syndrome.It can repair myocardial injury,improve cardiac function and effectively reduce adverse reactions in patients by improving inflammatory micro-environment.