脑微梗死与其他脑小血管病影像学标志物关联性的研究进展

Recent advance in correlation between cerebral micro-infarct and other imaging markers of cerebral small vessel disease

脑小血管病(CSVD)是一种老年人的常见疾病,其与认知功能障碍、神经心理障碍、运动障碍、步态异常以及排尿异常等相关。CSVD的影像学标志物主要包括近期皮质下小梗死、白质高信号、腔隙、血管周围间隙扩大、脑微出血、脑微梗死(CMI)和脑萎缩。目前关于CSVD影像学标志物之间的关联性、交互作用以及对临床症状的协同作用逐渐成为研究的热点。本文围绕CMI与其他CSVD影像学标志物关联性的研究进展进行综述,以期进一步阐明多种CSVD影像学标志物共存的发病机制,指导CSVD的防治。

Cerebral small vessel disease(CSVD)is a prevalent disease in elder people,which is related to cognitive dysfunction,neuropsychological disorder,motor and gait dysfunction,and urinary incontinence.The imaging markers of CSVD mainly include recent subcortical small infarct,lacuna,white matter hyperintensity,enlarged perivascular space,cerebral micro-bleed,cerebral micro-infarct,and cerebral atrophy.At present,the correlation and interaction of CSVD imaging markers and their synergistic effects on clinical symptoms have gradually become the research focus.This article reviews the correlations of cerebral micro-infarct with other CSVD imaging markers to further clarify the pathogenesis of coexistence of a variety of CSVD imaging markers and guide the prevention and treatment of CSVD.