维甲酸类化合物在AD防治中的作用机制研究进展

Recent advance in mechanism of retinoids in prevention and treatment of Alzheimer's disease

维甲酸类化合物是一类具有维甲酸类似结构或生物活性的天然或合成化合物。既往研究已经证明维甲酸类化合物可以通过多种途径改善阿尔茨海默病(AD)的病理及其症状。笔者现围绕维甲酸类化合物在AD防治中的作用机制方面的研究进展综述如下,以期为临床治疗AD方向的选择提供更多的参考依据。

Retinoids are a group of natural or synthetic compounds that have similar structures or biological activities as retinoic acid.Previous studies have demonstrated that retinoids can improve the pathophysiology and symptoms of Alzheimer's disease(AD)in a variety of ways.This article reviews the recent advance in mechanism of retinoids in the prevention and treatment of AD,in order to provide some references for selection of clinical treatment direction in AD.