PENTOCLO方案治疗局限型颞骨放射性骨坏死的疗效

Pentoxifylline-tocopherol-clodronate combination in the treatment of localized temporal bone osteoradionecrosis

目的:明确己酮可可碱、维生素E、氯膦酸盐(PENTOCLO)方案治疗局限型颞骨放射性骨坏死的疗效。方法:回顾性分析2020年11月至2021年4月期间在中山大学孙逸仙纪念医院21例(23耳)接受PENTOCLO方案治疗的局限型颞骨放射性骨坏死患者的临床资料,应用治疗前后患者主观症状及裸露骨质范围改善等指标评价该方案的疗效。结果:PENTOCLO方案的平均使用时间为(506±48)d。19侧患耳(82.6%)的耳痛、耳流脓症状完全消失;2侧患耳(8.7%)的症状好转。9侧患耳(39.1%)的外耳道裸露骨质已完全被皮肤覆盖;11侧患耳(47.8%)骨质裸露范围明显减小;3侧患耳(13.0%)骨坏死程度稳定。结论:PENTOCLO方案治疗局限型颞骨放射性骨坏死的疗效明确,可以作为治疗局限型颞骨放射性骨坏死的非手术方案。

Objective To determine the effects of pentoxifylline-tocopherol-clodronate combination(PENTOCLO)protocol in the treatment of localized temporal bone osteoradionecrosis(TBORN).Methods A retrospective analysis was conducted on the clinical data of 21 patients,who suffered localized TBORN(23 ears)and were treated with the PENTOCLO protocol in Sun Yat-sen Memorial Hospital,Sun Yat-sen University from November 2020 to April 2021.The curative effects of the PENTOCLO protocol were evaluated based on the changes in ear symptoms and the extent of exposed bone before and after treatment.Results The PENTOCLO protocol was applied for(506±48)d on average.As a result,19 ears(82.6%)became free of earache and purulent ear discharge,and two ears(8.7%)showed alleviation of symptoms.Moreover,nine ears(39.1%)exhibited re-epithelialization in the ear canal,11 ears(47.6%)showed a decrease in exposed ear canal bone,and the osteonecrosis of three ears(13.0%)was stable.Conclusions PENTOCLO has encouraging treatment effects on TBORN,and thus can be used as an effective nonsurgical option for localized TBORN.