复方斑蝥胶囊联合TC化疗方案治疗晚期卵巢癌的效果观察

Observation on effects of Compound Banmao Capsules combined with TC chemotherapeutic regimen for treating advanced ovarian cancer

目的探讨复方斑蝥胶囊联合TC化疗方案治疗晚期卵巢癌患者的疗效。方法以2018年4月至2020年4月于该院治疗的104例晚期卵巢癌患者为研究对象,随机分为试验组和对照组,每组52例。对照组患者采用TC化疗方案,试验组在对照组基础上联用复方斑蝥胶囊。比较两组患者疗效、免疫功能、不良反应发生情况和生活质量。结果试验组治疗后近期客观有效率(ORR)高于对照组(P<0.05),平均总生存期(OS)和中位无进展生存期(PFS)均显著长于对照组(P<0.05);试验组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平显著高于对照组(P<0.05),CD8^(+)水平显著低于对照组(P<0.05);试验组患者不良反应发生率显著低于对照组(P<0.05);试验组卡式评分显著高于对照组(P<0.05)。结论对于晚期卵巢癌患者,在使用TC化疗方案时联用复方斑蝥胶囊可提高治疗效果,改善患者免疫功能,减轻不良反应,提升生活质量。

Objective To explore the effects of Compound Banmao Capsules combined with TC chemotherapeutic regimen for treating the patients with advanced ovarian cancer.Methods A total of 104 patients with advanced ovarian cancer in the hospital from April 2018 to April 2020 served as the study subjects and were randomly divided into the experiment group and control group,52 cases in each group.The control group adopted the TC chemotherapeutic regimen and the experiment group conducted the combined use of Compound Banmao Capsules on the basis of the control group.The curative effect,immunologic function,adverse reaction occurrence and life quality were compared between two groups.Results The objective response rate(ORR)in the experiment group was higher than that in the control group(P<0.05),the mean overall survival(OS)and median progression free survival(PFS)in the experiment group were significantly longer than those in the control group(P<0.05);the CD3^(+),CD4^(+),CD4^(+)/CD8^(+)levels in the experiment group were significantly higher than those in the control group and the CD8^(+)level was significantly lower than that in the control group(P<0.05);the adverse reactions occurrence rate in the experiment group was significantly lower than that in control group(P<0.05);the KPS score in the experiment group was significantly higher than that in the control group(P<0.05).Conclusion For the patients with advanced ovarian cancer,Compound Banmao Capsules combined with TC chemotherapeutic regimen can effectively increase the curative effect,improve the immunity function,alleviate the adverse reactions and increase the life quality.