平足蛋白调控器官损伤与修复的研究进展

Research progress on podoplanin regulating organ injury and repair

平足蛋白(PDPN)是一种小分子跨膜糖蛋白,主要存在于基质细胞,参与淋巴管生成、血小板聚集、肿瘤侵袭和转移等过程。近年来越来越多研究结果显示,PDPN可表达于巨噬细胞、T细胞等多种免疫细胞,尤其在器官损伤后出现高表达,在调控炎症发生、器官耐受、组织纤维化和多种免疫相关性疾病中发挥重要作用。本文就近年来PDPN在器官损伤与修复中的调控机制进行综述,以期为器官损伤的防治提供新的靶点和研究方向。

Podoplanin(PDPN)is a small transmembrane mucin-like glycoprotein that mainly exists in stromal cells and is associated with lymphangiogenesis,platelet aggregation,tumor invasion,and metastasis.In recent years,numerous studies have demonstrated that PDPN was expressed in a variety of immune cells,including macrophages and T cells.Significantly,the up-regulated expression of PDPN occurs after organ damage,which plays a vital role in inflammation,organ tolerance,tissue fibrosis,and immune-related diseases.This article reviews the regulatory mechanism of PDPN in organ damage and repair to provide new targets and research directions for the prevention and treatment of organ damage.