摘要
Gastric cancer stem cells(CSCs),which refer to treatment-refractory and self-renewal cell populations,are critically involved in the initiation and progression of gastric cancer(GC).1 Although gastric CSCs populations have been validated across multiple studies,2 the precise molecular mechanisms of gastric CSCs properties maintenance remain unclear.Emerging evidences have highlighted the role of tripartite-motif(TRIM)family members in regulating CSCs self-renewal and differentiation through protein ubiquitination modification.3 However,the effects of TRIM family members on GC and gastric CSCs have not been elucidated.
基金
supported by the National Natural Science Foundation of China(No.81572350)
the Natural Science Youth Foundation of Jiangsu Province(No.BK20200115)
the National Natural Science Foundationof China for Young Scholars(No.82003025)
the Project Funding for Constructionof National and Provincial Key Clinical Specialty(No.Z155080000004).
