The interferon-γ receptor pathway:a new way to regulate CAR T cell-solid tumor cell adhesion

A recent study published in Nature by the Maus group represents a great discovery that the IFNγR pathway in solid tumors affected interactions with CAR T cells by affecting cell-binding duration and avidity.1 Adoptive cell therapy,particularly chimeric antigen receptor(CAR)T therapy,has shown significant clinical success in leukemia,lymphoma,and multiple myeloma patients.However,CAR T cell mediates solid tumor therapy with no equivalent successes in patients.