精神分裂症阴性症状与脑磁图静息状态下alpha频段能量的关系

The relationship between negative symptoms of schizophrenia and alpha-band power in resting magnetoencephalography

目的探究精神分裂症患者的阴性症状与静息状态下alpha波能量的关系。方法对符合ICD-10诊断标准的13例精神分裂症患者进行静息态(闭眼、清醒)下脑磁图扫描,通过时域下滑动窗短时能量方法计算alpha频段的能量,分别计算出左额叶、右额叶、左颞叶、右颞叶、左顶叶、右顶叶、左枕叶、右枕叶共8个脑区alpha能量值及其能量平均值;采用阳性与阴性症状量表评估精神分裂症患者的临床症状,并根据阴性症状得分将患者分为低阴性症状组(低于中位数)和高阴性症状组(高于中位数)。采用非参数秩和检验(Wilcoxon两样本秩和检验)比较2组alpha波总能量值及8个脑区alpha能量值的差异,采用多因素线性回归分析方法探索右颞区alpha能量与阴性症状的关系,采用协方差分析控制焦虑抑郁因子、受教育年限对阴性症状的影响,采用kendall′s tau-b进行相关分析,分析阴性症状与各脑区能量值的相关性。结果2组右颞叶alpha波能量值比较差异有统计学意义(Z=-2.143,P=0.032)。阴性症状量表分可由右颞叶能量、受教育年限、焦虑抑郁因子分、阳性症状量表分的变化表示(校正r2=0.894),而右颞叶能量值影响显著(t=3.965,P=0.004)。结论精神分裂症患者阴性症状可能与右颞叶能量异常有关。

Objective To explore the relationship between negative symptoms and resting alpha-band power in patients with schizophrenia.Method Thirteen patients with schizophrenia who met the ICD-10 diagnostic criteria were scanned by magnetoencephalography(MEG)in the eyes-closed resting state.The alpha-band powers were calculated using the short-time sliding window method in the time domain.The powers of eight brain regions include left frontal lobe,right frontal lobe,left temporal lobe,right temporal lobe,left parietal lobe,right parietal lobe,left occipital lobe and right occipital lobe.The average powers of these regions were obtained respectively.Clinical symptoms in patients with schizophrenia were assessed using the Positive and Negative Syndrome Scale(PANSS),which evaluated 30 items covering positive and negative symptoms and general psychopathology.The patients were then divided into the less negative symptom group(i.e.,a lower score than the median)and the highly negative symptom group(i.e.,a higher score than the median)according to the negative symptom scores.A nonparametric rank sum test,Wilcoxon two-sample rank sum test,was used to compare the difference between the two groups in the total alpha power and the alpha powers of eight brain regions.Multivariate linear regression was then used to analyze the relationship between the alpha power of the right temporal region and negative symptoms.Analysis of covariance was used to control for the confounding effects of anxiety and depression and years of education on the negative symptoms.Kendall′s tau-b analysis was used to explore the correlation between the negative symptoms and the alpha powers of eight brain regions.Result There was a significant difference(Z=-2.143,P=0.032)in the alpha powers of the right temporal lobe between the two groups.The negative symptom scale score can be contributed by the changes of alpha power in the right temporal lobe,years of education,anxiety and depression factor scores and positive symptom scale score(corrected r2=0.894).The alpha power of the right temporal lobe had a significant effect on negative symptoms(t=3.965,P=0.004).Conclusion The negative symptoms of schizophrenic patients may be related to the abnormal alpha power in the right temporal lobe.