肠道菌群代谢物对肠道上皮细胞线粒体的调控机制及中药干预研究进展

Research progress on the regulatory mechanism of intestinal flora metabolites on mitochondria of intestinal epithelial cells and the traditional Chinese medicine intervention

研究发现肠道菌群可直接或通过细胞核作用间接对肠道上皮细胞线粒体产生调控作用。这种调控作用与短链脂肪酸(SCFAs)、硫化氢(H2S)和一氧化氮(NO)等菌群代谢产物有关。这些代谢物参与线粒体相关的能量代谢过程和线粒体活性氧(mtROS)的产生,甚至整个机体的免疫反应。大量研究也显示,肠道菌群代谢物和线粒体已成为中药作用机制研究的热点,但二者的关联机制研究尚不深入。本综述就肠道菌群代谢物对肠道上皮细胞线粒体调控机制研究及中药干预进行总结,为中药靶向作用于肠道微生物与线粒体进而整体调控作用提供理论依据和启示。

It was found that intestinal flora could directly regulate mitochondria of intestinal epithelial cells or indirectly through the nucleus.This effect is associated with the flora metabolites such as short-chain fatty acids(SCFAs),hydrogen sulfide(H2S) and nitric oxide(NO).These metabolites are involved in mitochondria-related energy metabolic processes and the production of mitochondrial reactive oxygen species(mtROS),and even in the immune response of the whole organism.Numerous studies have also shown that intestinal flora metabolites and mitochondria have become a hot spot for research on the mechanism of action of traditional Chinese medicine,but the research on the mechanism of association between them is not yet in-depth.In this review,we summarize the mechanism of mitochondrial regulation of intestinal epithelial cells by intestinal flora metabolites and herbal interventions to provide a theoretical basis for targeting intestinal microbes and mitochondria to regulate body metabolism and health.