摘要
采用硅胶柱色谱、中压液相色谱、半制备高效液相色谱等分离技术,从姜黄95%乙醇提取物中分离得到1个新化合物。结合质谱、核磁、计算ECD等手段确定了化合物的结构及绝对构型,发现化合物为一个结构新颖的倍半萜类成分,将其命名为isoturmeronol B(1)。化合物1的骨架与没药烷型倍半萜相似,唯一区别在于化合物1在没药烷型倍半萜骨架的基础上,C-4位的甲基迁移至C-5位。对化合物1的抗炎和抗氧化活性进行了评价,结果表明化合物1无抗炎及抗氧化活性。
A new compound was isolated from the 95% ethanolic extract of the rhizomes of Curcuma longa L.using silica gel column chromatography,medium pressure liquid chromatography,and semi-preparative high performance liquid chromatography.The structure and absolute configuration of the compound was elucidated by HR-ESI-MS,NMR,and electronic circular dichroism(ECD) calculations.It is a novel sesquiterpenoid,which is named as isoturmeronol B(1).The carbon skeleton of compound 1 is similar to that of bisabolane-type sesquiterpenoid.The only difference is that the methyl group at C-4 in bisabolene-type sesquiterpenoid is migrated to C-5 in compound 1.Besides,the anti-inflammatory and antioxidant activities of the compound 1 were evaluated.The results showed that 1 has no anti-inflammatory and antioxidant activities.
作者
李泊雨
彭成
舒洪珍
刘菲
熊亮
LI Bo-yu;PENG Cheng;SHU Hong-zhen;LIU Fei;XIONG Liang(State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China,School of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China;Institute of Innovative Medicine Ingredients of Southwest Specialty Medicinal Materials,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China)
出处
《药学学报》
CAS
CSCD
北大核心
2022年第12期3603-3607,共5页
Acta Pharmaceutica Sinica
基金
国家自然科学基金优秀青年基金资助项目(82022072)
国家自然科学基金青年基金资助项目(81903777)。
关键词
姜黄
分离鉴定
新化合物
绝对构型
倍半萜
Curcuma longa L.
isolation and identification
new compound
absolute configuration
sesquiter-penoid