瞬时电位香草醛受体1与炎性疼痛

Transient potential vanillin receptor 1 and inflammatory pain

目的探究瞬时电位香草醛受体1(transient potential vanillin receptor 1,TRPV1)在炎性疼痛发生发展中的作用。方法采用Pubmed检索关键词“TRPV1”、“炎症”、“疼痛”、“激动剂”、“拮抗剂”等的相关文献,并将其进行归纳汇总。结果常见几种炎症因子激活TRPV1,参与炎性疼痛的信号传递。结论TRPV1在炎性疼痛产生的过程中发挥着至关重要的作用,通过对TRPV1进行抑制,开发基于TRPV1的受体拮抗剂,可以在一定程度上抑制炎性疼痛的产生。

Objective To investigate the role of transient potential vanillin receptor 1(TRPV1)in the development of inflammatory pain.Methods Pubmed was used to search the relevant literature on keywords“TRPV1”,“inflammation”,“pain”,“agonist”,“antagonist”and so on,and summarized them.Results Several inflammatory factors activate TRPV1 and participate in the signaling of inflammatory pain.Conclusion TRPV1 plays a crucial role in the production of inflammatory pain.By inhibiting TRPV1,the development of receptor antagonists based on TRPV1 can inhibit the production of inflammatory pain to a certain extent.