盐酸氨溴索注射液治疗老年慢性阻塞性肺疾病伴肺部感染的临床疗效及安全性

Clinical efficacy and safety of ambroxol hydrochloride injection in the treatment of chronic obstructive pulmonary disease with pulmonary infection in the elderly

目的 评价盐酸氨溴索注射液在老年慢性阻塞性肺疾病(慢阻肺)伴肺部感染患者临床治疗中有效性与安全性。方法 回顾性分析2019年4月—2021年4月上海市青浦区中医医院住院的老年慢阻肺伴肺部感染患者86例的临床资料,以其治疗方案的不同分为对照组和观察组,每组43例。对照组给予基础治疗方案(吸氧、止咳、解痉平喘、纠正酸碱失衡等),观察组在基础治疗方案上增加盐酸氨溴索注射液静注,2组疗程均为7 d。观察盐酸氨溴索注射液的临床有效性及安全性。结果 观察组总有效率明显高于对照组(P<0.01)。治疗后,观察组症状改善时间及住院时间比对照组明显缩短,血氧饱和度高于对照组(P<0.05),而IL6、 CRP、 PCT水平等炎症因子水平明显低于对照组(P<0.05)。2组不良反应发生率差异无统计学意义(P﹥0.05)。结论 盐酸氨溴索注射液可明显提高老年慢阻肺伴肺部感染患者的临床疗效,减轻肺部炎症,临床症状改善快,治疗时间缩短,且无明显的不良反应。

Objective To evaluate the efficacy and safety of ambroxol hydrochloride injection in the treatment of elderly patients with chronic obstructive pulmonary disease(COPD) and pulmonary infection. Methods The clinical data of 86 elderly patients with COPD complicated with pulmonary infection admitted to Traditional Chinese Medicine Hospital of Qingpu District from April 2019 to April 2021 were retrospectively analyzed. They were divided into control group and observation group according to the different treatment schemes, with 43 patients in each group. The control group was treated with basic treatment(oxygen inhalation, relieving cough, relieving spasm and asthma, correction of acid-base imbalance, etc.). The observation group added ambroxol hydrochloride injection for intravenous injection on the basis of the basic treatment. The course of treatment of both groups was 7 days. The clinical efficacy and safety of ambroxol hydrochloride injection were observed. Results The total effective rate of the observation group was significantly higher than that of the control group(P<0.01). After treatment, the improvement time of symptoms and hospital stay in the observation group were significantly shorter than those in the control group, the blood oxygen saturation was significantly higher than that in the control group and the levels of IL6, CRP, PCT and other inflammatory factors were significantly lower than those in the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion Ambroxol hydrochloride injection can significantly improve the clinical efficacy of elderly COPD patients with pulmonary infection, reduce pulmonary inflammation, improve clinical symptoms quickly, shorten the treatment time, and have no obvious adverse reactions.