吸入糖皮质激素在慢性阻塞性肺疾病合并肺癌患者中的使用争议

The controversy of inhaled corticosteroid on chronic obstructive pulmonary disease combined with lung cancer

慢性阻塞性肺疾病(简称慢阻肺)与肺癌密切相关,二者常常并存或先后发生,长期大量吸烟和高龄既是慢阻肺的主要危险因素,同时又是肺癌的主要高危因素。肺癌会显著影响慢阻肺的病情严重程度,并且被认为是患者导致死亡的重要原因。吸入糖皮质激素被推荐用于特定的慢阻肺患者,其对肺癌发展的潜在影响存在争议。本文针对临床研究证据对此进行阐述。

Chronic obstructive pulmonary disease is closely related to lung cancer and the two often co-existed or occurred succesively.Long term heavy smoking and old age is not only the main risk factors of COPD,but also the risk factor of lung cancer.Lung cancer imposes great impact on the severity of COPD and is considered as a major cause of the patients’mortality.Inhaled corticosteroid(ICS)is used in particular COPD patients.However,there is controversy of ICS on the development of lung cancer in COPD patients.We shall elaborate the clinical evidence in this review.