甲泼尼龙琥珀酸钠冲击疗法联合醒脑静注射液治疗病毒性脑膜炎患者的效果

Effects of Methylprednisolone sodium succinate pulse therapy combined with Xingnaojing injection on patients with viral meningitis

目的:观察甲泼尼龙琥珀酸钠冲击疗法联合醒脑静注射液治疗病毒性脑膜炎患者的效果。方法:选取2019年3月至2020年6月该院收治的60例病毒性脑炎患者进行前瞻性研究,按照随机数字表法分为对照组和观察组各30例。对照组给予常规治疗,观察组在对照组基础上给予甲泼尼龙琥珀酸钠冲击疗法联合醒脑静注射液治疗。比较两组疗效、治疗前后T细胞亚群指标(CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))水平、血清免疫球蛋白[免疫球蛋白(Ig)A、IgG和IgM]水平和红细胞免疫功能指标[红细胞免疫复合物花环率(RBC-ICR)、免疫黏附促进因子(FEER)、红细胞C_(3)b受体花环率(RBC-C_(3)bR)]水平。结果:观察组治疗总有效率为96.67%,明显高于对照组的73.33%,差异有统计学意义(P<0.05);治疗后,两组CD4^(+)、CD4^(+)/CD8^(+)、IgA、IgG、IgM、RBC-C_(3)bR、FEER水平均高于治疗前,且观察组高于对照组,两组RBC-ICR、CD8^(+)水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。结论:在常规治疗基础上采用甲泼尼龙琥珀酸钠冲击疗法联合醒脑静注射液治疗脑膜炎患儿可提高治疗总有效率和血清免疫球蛋白水平,改善T细胞亚群指标和红细胞免疫功能指标水平,优于单纯常规治疗效果。

Objective:To observe effects of Methylprednisolone sodium succinate pulse therapy combined with Xingnaojing injection on patients with viral meningitis.Methods:A prospective study was conducted on 60 patients with viral encephalitis admitted to the hospital from March 2019 to June 2020.According to the random number table method,they were divided into control group and observation group,30 cases in each.The control group was given routine treatment,while the observation group was given Methylprednisolone sodium succinate pulse therapy combined with Xingnaojing injection on the basis of that of the control group.The efficacy,the levels of T cell subsets(CD4^(+),CD8^(+),CD4^(+)/CD8^(+)),the serum immunoglobulin index levels(IgA,IgG,IgM),and the erythrocyte immune function index levels[erythrocyte immune complex rosette rate(RBC-ICR),immune adhesion promoting factor(FEER),erythrocyte C_(3)b receptor rosette rate(RBC-C_(3)bR)]were compared between the two groups before and after the treatment.Results:The total effective rate of treatment in the observation group was 96.67%,which was significantly higher than 73.33%in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of CD4^(+),CD4^(+)/CD8^(+),IgA,IgG,IgM,RBC-C_(3)bR and FEER in the two groups were higher than those before the treatment,and those in the observation group were higher than those in the control group;the levels of RBC-ICR and CD8^(+)in the two groups were lower than those before the treatment,and those in the observation group were lower than those in the control group;and the differences were statistically significant(P<0.05).Conclusions:On the basis of the conventional treatment,Methylprednisolone sodium succinate pulse therapy combined with Xingnaojing injection in the treatment of the children with meningitis can improve the total effective rate of treatment and the serum immunoglobulin index levels and improve the T cell subset index levels and the erythrocyte immune function index levels.Moreover,it is superior to single routine treatment.