四磨汤口服液联合酪酸梭菌二联活菌散治疗小儿消化不良性腹泻的效果

Effects of Simo decoction oral liquid combined with live combined Clostridium butyricum and Bifidobacterium powders in treatment of infantile dyspeptic diarrhea

目的:探讨四磨汤口服液联合酪酸梭菌二联活菌散治疗小儿消化不良性腹泻的效果。方法:回顾性分析2020年6月至2021年6月该院收治的86例消化不良性腹泻患儿的临床资料,按照治疗方式不同分为对照组和观察组各43例。两组患儿均采用蒙脱石散治疗,在此基础上对照组口服酪酸梭菌二联活菌散,观察组在对照组基础上联用四磨汤口服液,比较两组临床疗效、临床症状缓解时间、治疗前后免疫功能指标水平,以及不良反应发生率。结果:观察组治疗总有效率为90.70%(39/43),高于对照组的69.77%(30/43),差异有统计学意义(P<0.05);观察组患儿大便次数、性状恢复正常时间及呕吐、腹痛消失时间均短于对照组,差异有统计学意义(P<0.05);治疗后,观察组CD4^(+)、CD4^(+)/CD8^(+)、免疫球蛋白(Ig)A、IgG水平均高于对照组,CD8^(+)水平显著低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:四磨汤口服液联合酪酸梭菌二联活菌散治疗小儿消化不良性腹泻能提高治疗总有效率,缩短患儿临床症状消失时间,提升机体免疫功能,且安全性良好。

Objective:To explore effects of Simo decoction oral liquid combined with live combined Clostridium butyricum and Bifidobacterium powders in treatment of infantile dyspeptic diarrhea.Methods:A retrospective analysis of 86 children with dyspeptic diarrhea admitted to the hospital from June 2020 to June 2021 was performed.According to different treatment methods,they were divided into control group and observation group,43 cases in each.The two groups were treated with montmorillonite powder,on the basis of which the control group was given oral Clostridium caseinate live powder,and the observation group was given Simotang oral solution on the basis of the control group.The clinical efficacy,the duration of clinical symptom relief,the level of immune function indicators before and after treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 90.70%(39/43),which was higher than 69.77%(30/43)of the control group,and the difference was statistically significant(P<0.05).The stool frequency,the trait recovery time,and the vomiting and abdominal pain disappearance time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of CD4^(+),CD4^(+)/CD8^(+),immunoglobulin(Ig)A and IgG were higher than those in the control group;the level of CD8^(+) was significantly lower than that in control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Simo decoction oral liquid combined with live combined Clostridium butyricum and Bifidobacterium powders in the treatment of the children with dyspeptic diarrhea can improve the total effective rate,shorten the clinical symptom disappearance time,improve the immune function,and has good safety.