宫颈癌组织中Survivin、ICAM-3的表达及与放疗敏感性的关系

Expression of Survivin and ICAM-3 in Cervical Cancer Tissues and Their Relationship with Radiotherapy Sensitivity

目的 探究宫颈癌组织中Survivin、ICAM-3的表达及与放疗敏感性的关系。方法 选取宫颈癌患者50例,根据放疗敏感性的不同将患者分为放疗敏感组(n=28)和放疗抵抗组(n=22)。采用免疫组化分析宫颈癌患者的Survivin、ICAM-3水平,比较其和临床病理特征及放疗敏感性的关系。结果 放疗敏感组和放疗抵抗组的FIGO分期差异无统计学意义(P>0.05),放疗抵抗组肿瘤的分化程度更低,肿瘤直径更大,差异有统计学意义(P<0.05)。放疗敏感组Survivin、ICAM-3的阳性表达率明显低于放疗抵抗组,差异有统计学意义(P<0.05)。多因素分析结果发现,分化程度、肿瘤直径与放疗敏感性无关(P>0.05),Survivin、ICAM-3表达水平与放疗敏感性有关(P<0.05)。结论 宫颈癌患者Survivin、ICAM-3水平以及临床病理特征与放疗敏感性有关,可为今后探索宫颈癌的预后指标提供一定的参考依据。

Objective To investigate the expression of Survivin and ICAM-3 in cervical cancer tissues and their relationship with radiotherapy sensitivity.Methods 50 patients with cervical cancer were divided into radiotherapy sensitive group(n=28) and radiotherapy resistant group(n=22).Immunohistochemistry was used to analyze Survivin and ICAM-3 levels in patients with cervical cancer, and the relationship between survivin and ICAM-3 levels and clinicopathological features and radiotherapy sensitivity were compared.Results There was no significant difference in FIGO stage between radiotherapy sensitive group and radiotherapy resistant group(P>0.05).The tumor differentiation degree and tumor diameter of radiotherapy resistant group were lower, and the difference was statistically significant(P<0.05).The positive expression rates of Survivin and ICAM-3 in the radiotherapy sensitive group were significantly lower than those in the chemotherapy resistance group(P<0.05).The results of multivariate analysis showed that the degree of differentiation and tumor diameter were not related to the sensitivity of radiotherapy(P>0.05),while the expression levels of Survivin and ICAM-3 were related to the sensitivity of radiotherapy(P<0.05).Conclusion The levels of Survivin, ICAM-3 and clinicopathological features in patients with cervical cancer are related to the sensitivity of radiotherapy, which provides a certain reference for exploring the prognostic indicators of cervical cancer in the future.