益胃消瘀颗粒对慢性萎缩性胃炎血清胃功能的影响

The effect of Yiwei Xiaoyu Granules on serum gastric function in chronic atrophic gastritis

目的 为了评估益胃消瘀颗粒对慢性萎缩性胃炎(CAG)患者血清胃功能的影响。方法 通过设计随机、双盲、阳性药物对照试验,评估益胃消瘀颗粒对CAG患者血清胃功能的影响,包括胃蛋白酶原(PG)Ⅰ、PGⅡ、PGⅠ/PGⅡ值(PGR)及胃泌素-17(G-17)。通过招募72例幽门螺杆菌(Hp)阴性的CAG患者,按照1∶1比例随机进入试验组或对照组,试验组获得益胃消瘀颗粒+胃复春模拟剂,对照组获得胃复春片+益胃消瘀颗粒模拟剂,治疗疗程为24周。治疗前后均用酶联免疫吸附(ELISA)检测患者血清胃功能相关指标。结果 治疗24周后,试验组CAG患者PGⅠ、PGR较治疗前明显升高(P<0.05),对照组G-17水平较治疗前降低(P<0.05)。经治疗后两组对比发现,试验组PGⅠ、PGR水平明显高于对照组(P<0.05),而PGⅡ未见明显差异(P>0.05),试验组CAG患者血清G-17表达水平明显高于对照组。结论 益胃消瘀颗粒可明显改善CAG患者血清胃功能水平。

Objective To evaluate the effect of Yiwei Xiaoyu Ganules(YWXY) on serum gastric function in chronic atrophic gastritis(CAG).Methods By designing the double-blind, randomized, positive medicine-controlled trial, the effect of YWXY on serum gastric function was evaluated, including pepsinogen-Ⅰ(PGⅠ),PGⅡ,PGⅠ/PGⅡ ratio(PGR) and gastrin-17(G-17).Seventy-two patients with Helicobacter pylori(Hp) negative CAG were recruited and randomly entered the experiment group or control group by a ratio of 1∶1.The experiment group obtained YWXY and Weifuchun simulation preparation(WFC).The control group obtained Weifuchun and YWXY simulation preparation.The treatment course lasted for 24 weeks.Serum gastric function related indexes before and after treatment were detected by the enzyme linked immunosorbent assay(ELISA).Results After 24-week treatment, the level of PGⅠ and PGR in the experiment group were significantly increased compared with before treatment(P<0.05),while the G-17 level in the control group was decreased compared with before treatment(P<0.05).The comparison between the two groups after treatment found that the PGⅠ and PGR levels in the experiment group were significantly higher those in the control group(P<0.05),while PGⅡ had no significant difference(P>0.05).The serum G-17 expression level in the experiment group was significantly higher than that in the control group.Conclusion YWXY can significantly improve the serum gastric function level in the patients with CAG.