长非编码RNA通过调控磷酸甘油激酶1影响肿瘤细胞增殖的研究进展

Study progress of long non-coding RNA affecting tumor cells proliferation by regulating phosphoglycerate kinase 1

磷酸甘油激酶1(PGK1)在肿瘤细胞中存在高表达,并通过多种信号转导通路,促进肿瘤细胞的增殖和转移,与其不良预后密切相关。长非编码RNA(lncRNA)具有多样的调控机制,从染色质重塑、转录调控及转录后加工等多个层面对基因表达进行调节。既往很多研究表明,lncRNA可通过调控PGK1影响恶性肿瘤细胞的增殖。本文主要就这一核心问题展开综述。

Phosphoglycerate kinase 1(PGK1) is highly expressed in tumor cells and promotes the proliferation and metastasis of tumor cells through a variety of signal transduction pathways, which is closely correlated to its poor prognosis.Long non coding RNA(lncRNA) has a variety of regulatory mechanisms to regulate the gene expression from the multiple aspects of chromatin remodeling, transcriptional regulation and post-transcriptional processing.Many previous studies have shown that lncRNA affects the proliferation of malignant tumor cells by regulating PGK1.The paper mainly summarizes this core issue.